ArticleBMC microbiology2010
NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection.Communications biology · 2023Article
- General Phenotype of NADase Induction by CLI Treatment inInternational journal of microbiology · 2022Article
- Tryptophan Metabolism: A Versatile Area Providing Multiple Targets for Pharmacological Intervention.Egyptian journal of basic and clinical pharmacology · 2019Article
- Binding of NADmBio · 2017Article
- Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects.International journal of tryptophan research : IJTR · 2017Review
- NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.PLoS pathogens · 2016Article
- Exploring NAD+ metabolism in host-pathogen interactions.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Relevance of the two-component sensor protein CiaH to acid and oxidative stress responses in Streptococcus pyogenes.BMC research notes · 2014Article
- Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.BMC research notes · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNAD-glycohydrolase (NADase) secreted by M-1 group A streptococcal (GAS) isolates are suspected as one of the virulence factors to cause severe invasive disease including streptococcal toxic shock-like syndrome (STSS). M-1 GAS strains were divided into three groups based on NADase activity: high activity, low activity and no activity in our previous report.
resultsThe representative high activity isolates taken from STSS patients showed higher virulence compared with isolates from the low activity group, when used to infect mice. The knockout mutant of the nga gene, which encodes NADase also showed reduced virulence in a mouse infection study. The cloned nga gene was able to significantly complement the lost virulence. In addition, the solution containing purified recombinant IFS, which is an inhibitor of NADase, partially rescued mice infected with S. pyogenes.
conclusionsThese results indicate that NADase is important for the virulence of S. pyogenes in vivo and is the potential target to suppress the virulence.
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