ArticleBMC veterinary research2010
Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance.
Article in BMC veterinary research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Incorporating farm animal models for the study of neuropsychiatric diseases: Expansion of the possibilities.Cognitive, affective & behavioral neuroscience · 2026Review
- Space-time distribution of classical scrapie in Italian sheep: assessing the effectiveness of the National Genetic Selection Plan.Veterinary research · 2025Article
- Predicted breeding values for relative scrapie susceptibility for genotyped and ungenotyped sheep.Genetics, selection, evolution : GSE · 2024Article
- Large animal models for chronic wasting disease.Cell and tissue research · 2023Review
- Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer.Viruses · 2021Article
- Prediction of Genetic Resistance for Scrapie in Ungenotyped Sheep Using a Linear Animal Model.Genes · 2021Article
- Detection by real-time quaking-induced conversion (RT-QuIC), ELISA, and IHC of chronic wasting disease prion in lymph nodes from Pennsylvania white-tailed deer with specificJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains.Scientific reports · 2021Article
- Article
- Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage.BMC veterinary research · 2018Article
- Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats.Veterinary research · 2018Article
- Article
- Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis.Heliyon · 2018Article
- Scientific opinion on chronic wasting disease (II).EFSA journal. European Food Safety Authority · 2018Article
- Modelling of strategies for genetic control of scrapie in sheep: The importance of population structure.PloS one · 2018Article
- Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion.The Journal of general virology · 2017Article
- Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic.Journal of applied genetics · 2017Article
- Article
- Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion.Journal of clinical microbiology · 2016Article
- Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats.BMC veterinary research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSusceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding. From 2002 onwards EU regulations required intensive active scrapie surveillance as well as certain control measures in affected flocks.Here we analyze the data on genotype frequencies and scrapie prevalence in the Dutch sheep population obtained from both surveillance and affected flocks, to identify temporal trends. We also estimate the genotype-specific relative risks to become a detected scrapie case.
resultsWe find that the breeding programme has produced a steady increase in the level of genetic scrapie resistance in the Dutch sheep population. We also find that a significant decline in the prevalence of scrapie in tested animals has occurred a number of years after the start of the breeding programme. Most importantly, the estimated scrapie prevalence level per head of susceptible genotype is also declining significantly, indicating that selective breeding causes a population effect.
conclusionsThe Dutch scrapie control programme has produced a steady rise in genetic resistance levels in recent years. A recent decline in the scrapie prevalence per tested sheep of susceptible prion protein genotype indicates that selective breeding causes the desired population effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.