ArticleJournal of translational medicine2010
Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients.
Article in Journal of translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias.Genes and immunity · 2020Article
- Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs.BioMed research international · 2020Article
- DNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire.Oncotarget · 2016Article
- The alteration and clinical significance of Th22/Th17/Th1 cells in patients with chronic myeloid leukemia.Journal of immunology research · 2015Article
- Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants.Computational and structural biotechnology journal · 2014Review
- The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies.Journal of hematology & oncology · 2013Review
- Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML.Cancer cell international · 2013Article
- New insights into antigen specific immunotherapy for chronic myeloid leukemia.Cancer cell international · 2012Article
- Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia.Journal of hematology & oncology · 2012Article
- Upregulated TCRζ enhances interleukin-2 production in T-cells from patients with CML.DNA and cell biology · 2012Article
- Post-thymic maturation: young T cells assert their individuality.Nature reviews. Immunology · 2011Review
- Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation.Journal of hematology & oncology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundT-cell immunodeficiency is a common feature in cancer patients, which may relate to initiation and development of tumor. Based on our previous finding, to further characterize the immune status, T cell proliferative history was analyzed in CD4+ and CD8+ T cells from chronic myeloid leukemia (CML) patients.
methodsQuantitative analysis of deltaRec-psiJalpha signal joint T cell receptor excision circles (sjTRECs) was performed in PBMCs, CD3+, CD4+ and CD8+T cells by real-time PCR, and the analysis of 23 TRBV-D1 sjTRECs was performed by semi-nested PCR. Forty eight CML cases in chronic phase (CML-CP) were selected for this study and 17 healthy individuals served as controls.
resultsThe levels of deltaRec-psiJalpha sjTRECs in PBMCs, CD3+, CD4+, and CD8+ T cells were significantly decreased in CML patients, compared with control groups. Moreover, the numbers of detectable TRBV subfamily sjTRECs, as well as the frequency of particular TRBV-BD1 sjTRECs in patients with CML were significantly lower than those from healthy individuals.
conclusionsWe observed decreased levels of recent thymic emigrants in CD4+ and CD8+ T cells that may underlay the persistent immunodeficiency in CML patients.
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