ArticleInfection control and hospital epidemiology2010
Failure of routine diagnostic methods to detect influenza in hospitalized older adults.
Article in Infection control and hospital epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 40 citations in OpenAlex.
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- Underdiagnosis of Influenza Virus Infection in Hospitalized Older Adults.Journal of the American Geriatrics Society · 2018Article
- Sensitive Diagnostics Confirm That Influenza C is an Uncommon Cause of Medically Attended Respiratory Illness in Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
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- Performance of rapid SOFIA Influenza A+B test compared to Luminex x-TAG respiratory viral panel assay in the diagnosis of influenza A, B, and subtype H3.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Article
- Survey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012-2013.Influenza and other respiratory viruses · 2016Article
- Improving Accuracy of Influenza-Associated Hospitalization Rate Estimates.Emerging infectious diseases · 2015Article
- Estimating influenza disease burden from population-based surveillance data in the United States.PloS one · 2015Article
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- Respiratory syncytial virus- and human metapneumovirus-associated emergency department and hospital burden in adults.Influenza and other respiratory viruses · 2014Article
- Clinical diagnosis of pandemic A(H1N1) 2009 influenza in children with negative rapid influenza diagnostic test by lymphopenia and lower C-reactive protein levels.Influenza and other respiratory viruses · 2014Article
- Estimating influenza incidence and rates of influenza-like illness in the outpatient setting.Influenza and other respiratory viruses · 2013Article
- Real-time reverse transcriptase PCR assay for improved detection of human metapneumovirus.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo define the utility of using routine diagnostic methods to detect influenza in older, hospitalized adults.
designDescriptive study.
settingOne academic hospital and 1 community hospital during the 2006-2007 and 2007-2008 influenza seasons. Participants. Hospitalized adults 50 years of age or older.
methodsAdults who were 50 years of age or older and hospitalized with symptoms of respiratory illness were enrolled and tested for influenza by use of reverse-transcriptase polymerase chain reaction (RT-PCR). Using RT-PCR as the gold standard, we assessed the performances of rapid antigen tests and conventional influenza culture and the diagnostic use of the clinical definition of influenza-like illness.
resultsInfluenza was detected by use of RT-PCR in 26 (11%) of 228 patients enrolled in our study. The sensitivity of the rapid antigen test performed at bedside by research staff members was 19.2% (95% confidence interval, 8.51%-37.9%); the sensitivity of conventional influenza culture was 34.6% (95% confidence interval, 19.4%-53.8%). The ability to detect influenza with both the rapid antigen test and culture was associated with patients with a higher viral load (P=.002 and P=.001, respectively). The ability to diagnose influenza by use of the clinical definition of influenza-like illness had a higher sensitivity (80.8%) but lacked specificity (40.6%).
conclusionBecause rapid antigen testing and viral culture have poor sensitivity (19.2% and 34.6%, respectively), neither testing method is sufficient to use to determine what type of isolation procedures to implement in a hospital setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.