ArticleSleep2010
Circadian regulation of sleep and the sleep EEG under constant sleep pressure in the rat.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.PloS one · 2025Article
- Sleep alterations as a function of 88 health indicators.BMC medicine · 2024Article
- Modeling Drosophila sleep: fly in the sky?Sleep · 2024Article
- Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.Nature protocols · 2023Review
- Analysis of circadian rhythm components in EEG/EMG data of aged mice.Frontiers in neuroscience · 2023Article
- Article
- Disrupted Sleep Homeostasis and Altered Expressions of Clock Genes in Rats with Chronic Lead Exposure.Toxics · 2021Article
- Effects of circadian misalignment on sleep in mice.Scientific reports · 2018Article
- Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?Neurobiology of sleep and circadian rhythms · 2018Review
- The adenosine-mediated, neuronal-glial, homeostatic sleep response.Current opinion in neurobiology · 2017Review
- Dim light at night disturbs the daily sleep-wake cycle in the rat.Scientific reports · 2016Article
- The Neurobiology of Sleep and Wakefulness.The Psychiatric clinics of North America · 2015Review
- Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep.PloS one · 2014Article
- Adolescent sleep patterns in humans and laboratory animals.Hormones and behavior · 2013Review
- Estradiol suppresses recovery of REM sleep following sleep deprivation in ovariectomized female rats.Physiology & behavior · 2011Article
- Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.Sleep · 2011Article
- Hippocampal memory consolidation during sleep: a comparison of mammals and birds.Biological reviews of the Cambridge Philosophical Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveSleep is regulated by homeostatic and circadian processes. Slow wave activity (SWA; 1-4 Hz) in the NREM sleep electroencephalogram (EEG) reflects sleep homeostasis. Activity of faster EEG frequencies (10-25 Hz) is thought to be under influence of circadian factors. The relative contribution of both processes to the distribution of sleep and wakefulness and EEG activity in rodents remains uncertain.
designContinuous EEG recording in rats in constant dark conditions (DD) were performed and a sleep deprivation protocol consisting of 2 h sleep deprivation followed by 2 h of rest (2h/2h) was applied for 48 h to obtain a constant sleep pressure. SETTINGS: Basic sleep research laboratory. PATIENTS OR
participantsAdult male Wistar rats.
interventionSleep deprivation. MEASUREMENTS AND
resultsUnder the 2h/2h protocol, the circadian modulation of waking, NREM and REM sleep was markedly reduced compared to the baseline, affecting the frequency of vigilance state episodes and the duration of REM sleep and waking episodes. In contrast, NREM sleep episode duration still showed a daily modulation. Consecutive 2h values of SWA in NREM sleep were stabile during the 2h\2h protocol, while NREM sleep EEG activity within the higher frequencies (7-25 Hz) still demonstrated strong circadian modulation, which did not differ from baseline.
conclusionsIn rats, the daily modulation of REM sleep is less pronounced compared to NREM sleep and waking. In contrast to SWA, activity in higher frequencies (7-25 Hz) in the NREM sleep EEG have an endogenous circadian origin and are not influenced by sleep homeostatic mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.