ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review.Frontiers in psychiatry · 2022Pooled it
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.Journal of personalized medicine · 2022Article
- A genetic correlation and bivariate genome-wide association study of grip strength and depression.PloS one · 2022Article
- History of suicidality and alcohol craving trajectories during inpatient treatment for alcohol use disorder.Drug and alcohol dependence · 2020Article
- Association of PPM1G methylation with risk-taking in alcohol use disorder.Scientific reports · 2020Article
- Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.BMC psychiatry · 2020Article
- Genetic determinants of beverage consumption: Implications for nutrition and health.Advances in food and nutrition research · 2019Review
- Genetic influences on conduct disorder.Neuroscience and biobehavioral reviews · 2018Review
- High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model.PLoS genetics · 2016Article
- Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.Molecular psychiatry · 2016Article
- Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.The American journal of psychiatry · 2015Article
- Adult neuropsychiatric expression and familial segregation of 2q13 duplications.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.Stem cell research · 2014Article
- General and substance-specific predictors of young adult nicotine dependence, alcohol use disorder, and problem behavior: replication in two samples.Drug and alcohol dependence · 2014Article
- A brief history of research on the genetics of alcohol and other drug use disorders.Journal of studies on alcohol and drugs. Supplement · 2014Review
- Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Molecular psychiatry · 2014Article
- Translational behaviour-genetic studies of alcohol: are we there yet?Genes, brain, and behavior · 2012Review
- Twin study of the relationship between adolescent attention-deficit/hyperactivity disorder and adult alcohol dependence.Journal of studies on alcohol and drugs · 2012Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Twin studies provide strong evidence that there is a shared genetic liability that predisposes to a number of different psychiatric outcomes related to behavioral disinhibition. Further, alcohol dependence comorbid with other disinhibitory disorders is particularly heritable. Chromosome 2p14-2q14.3 has been linked to multiple psychiatric conditions related to behavioral undercontrol. In the Collaborative Study on the Genetics of Alcoholism (COGA), we previously reported linkage to this region with alcohol dependence (AD), suicide attempts (SUI), and conduct disorder (CD). In this study, we follow-up on these previous reports of linkage by combining the phenotypes in analyses that jointly consider the presence of multiple conditions. Linkage analyses of the combined phenotype of AD with CD or SUI results in a maximum LOD score of 5.4 in this region. In addition to this primary linkage peak, independent samples have reported linkage to other alcohol-related phenotypes across chromosome 2. Accordingly, we followed-up these linkage signals by testing for association with SNPs across chromosome 2 in a case-control sample, in which a subset of the cases consisted of alcohol-dependent probands from the linkage sample. We find evidence of association with the combined AD with CD or SUI phenotype, with 23 genes surviving permutation testing. The number of associated genes across the chromosome may explain the persistent linkage findings reported on chromosome 2 across a number of independent studies of alcohol and disinhibitory phenotypes. Further, none of the genes were located directly under the primary COGA linkage peak, which has implications for association tests following-up linkage peaks.
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