ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
Association study of 182 candidate genes in anorexia nervosa.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 93 citations in OpenAlex.
- From Lab to Clinic and Farm: LeveragingBiology · 2025Review
- Anti-hypothalamus autoantibodies in anorexia nervosa: a possible new mechanism in neuro-physiological derangement?Eating and weight disorders : EWD · 2022Article
- Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain.Neuroscience · 2021Article
- Childhood trauma determines different clinical and biological manifestations in patients with eating disorders.Eating and weight disorders : EWD · 2021Observational
- Genetic risk factors for eating disorders: an update and insights into pathophysiology.Therapeutic advances in psychopharmacology · 2019Review
- Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics.International journal of bipolar disorders · 2018Article
- The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.Contemporary clinical trials · 2018Article
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- Convergent and divergent genetic changes in the genome of Chinese and European pigs.Scientific reports · 2017Article
- The Eating-Disorder Associated HDAC4Biological psychiatry · 2017Article
- Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors.PloS one · 2017Article
- A novel relationship for schizophrenia, bipolar and major depressive disorder Part 5: a hint from chromosome 5 high density association screen.American journal of translational research · 2017Article
- Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders.Eating and weight disorders : EWD · 2016Article
- BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice.Translational psychiatry · 2016Article
- Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa.Molecular psychiatry · 2016Article
- Machine learning derived risk prediction of anorexia nervosa.BMC medical genomics · 2016Article
- New Insights in Anorexia Nervosa.Frontiers in neuroscience · 2016Review
- The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population.PloS one · 2016Article
- Canonical genetic signatures of the adult human brain.Nature neuroscience · 2015Article
- Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders.The pharmacogenomics journal · 2015Article
Corrections and comments
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Authors and funding
27 authors at 20 institutions in 6 countries.
Funding
Abstract
We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate genes), brain expression, biological plausibility, and estrogen responsivity. We employed a case-control design that tested each SNP individually as well as haplotypes derived from these SNPs in 1,085 case individuals with AN diagnoses and 677 control individuals. We also performed separate association analyses using three increasingly restrictive case definitions for AN: all individuals with any subtype of AN (All AN: n = 1,085); individuals with AN with no binge eating behavior (AN with No Binge Eating: n = 687); and individuals with the restricting subtype of AN (Restricting AN: n = 421). After accounting for multiple comparisons, there were no statistically significant associations for any individual SNP or haplotype block with any definition of illness. These results underscore the importance of large samples to yield appropriate power to detect genotypic differences in individuals with AN and also motivate complementary approaches involving Genome-Wide Association (GWA) studies, Copy Number Variation (CNV) analyses, sequencing-based rare variant discovery assays, and pathway-based analysis in order to make up for deficiencies in traditional candidate gene approaches to AN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.