ArticleFish physiology and biochemistry2010
Cloning, characterization, and expression analysis of a CC chemokine gene from turbot (Scophthalmus maximus).
Article in Fish physiology and biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 32 citations in OpenAlex.
- Analysis of Manifestation of CC and CXC Chemokine Genes in Olive Flounders (Development & reproduction · 2018Article
- CK12a, a CCL19-like Chemokine That Orchestrates both Nasal and Systemic Antiviral Immune Responses in Rainbow Trout.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Chemokine receptor CXCR3 in turbot (Scophthalmus maximus): cloning, characterization and its responses to lipopolysaccharide.Fish physiology and biochemistry · 2016Article
- Identification and expression analysis of a CC chemokine from cobia (Rachycentron canadum).Fish physiology and biochemistry · 2013Article
- Molecular cloning, characterization and expression analysis of a CC chemokine gene from miiuy croaker (Miichthys miiuy).Fish physiology and biochemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chemokines are a superfamily of chemotactic cytokines playing an important role in leukocyte chemotaxis. Here, a turbot head kidney cDNA library was constructed in which KC70 was identified as a CC chemokine. Unknown 5' and 3' parts of the cDNA were amplified by 5' and 3' rapid amplification of cDNA ends (RACE). The complete cDNA of KC70 contains a 59-bp 5' UTR, a 336-bp ORF, and a 152-bp 3' UTR. Four exons and three introns were identified in KC70. Phylogenetic analysis showed that KC70 was similar to CCL19. In normal turbot KC70 was expressed in all tissues except brain and skin. Infection of turbot with pathogenic bacteria significantly increased expression of KC70 in the liver. Expression of KC70 in head kidney first increased and then decreased after bacterial challenge. No significant change was observed in the spleen after bacterial challenge. During embryonic development, KC70 was highly expressed after the gastrula stage. These results indicated KC70 plays important and multiple roles in turbot immune response.
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Registered trials
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