ArticleMolecular imaging and biology2011
Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Development of Chincho (Gels (Basel, Switzerland) · 2022Article
- MRI Contrast Agents in Glycobiology.Molecules (Basel, Switzerland) · 2022Review
- Systematic overview of soft materials as a novel frontier for MRI contrast agents.RSC advances · 2020Review
- CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T.Theranostics · 2020Article
- Preparation and Nanoencapsulation of Lectin fromBioMed research international · 2020Article
- A new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study.Journal of nanobiotechnology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES: Chitosan nanoparticles were prepared from 85% deacetylated chitin by glutaraldehyde cross-linking of an aqueous acetic acid dispersion of chitosan in a mixture of n-hexane using sodium bis(ethylhexyl)sulfosuccinate as a surfactant.
resultsSeveral crucial parameters, namely, the Gd and protein content of the nanoparticles, their size and dispersity were determined. Magnetic resonance measurements were carried out by intravenous perfusion of mono-disperse suspensions of the nanoparticles into mice.
conclusionsChitosan nanoparticles can be used as contrast agents in magnetic resonance imaging (MRI). They are excellent candidates for controlled delivery of bioactive compounds to molecular targets and as biospecific diagnostic tools in MRI.
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Registered trials
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