ArticleThe open immunology journal2010
Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise.
Article in The open immunology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Managing fibromyalgia with complementary and alternative medical exercise: a systematic review and meta-analysis of clinical trials.Rheumatology international · 2022Pooled it
- Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review.Arthritis research & therapy · 2015Pooled it
- Are depression, anxiety and poor mental health risk factors for knee pain? A systematic review.BMC musculoskeletal disorders · 2014Pooled it
- Systematic review with meta-analysis: cytokines in fibromyalgia syndrome.BMC musculoskeletal disorders · 2011Pooled it
- NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10.Antioxidants & redox signaling · 2014Trial
- Changes in pain and insulin-like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides.Arthritis research & therapy · 2012Trial
- Article
- Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome.Frontiers in molecular neuroscience · 2024Review
- Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in medicine · 2021Article
- Mental Disorders, Musculoskeletal Disorders and Income-Driven Patterns: Evidence from the Global Burden of Disease Study 2017.Journal of clinical medicine · 2020Article
- T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives.International journal of molecular sciences · 2020Review
- Article
- Association of derived patterns of musculoskeletal disorders with psychological problems: a latent class analysis.Environmental health and preventive medicine · 2019Article
- Article
- Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome.Frontiers in cellular neuroscience · 2019Review
- Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports.Toxicology reports · 2018Article
- Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells.The Journal of pharmacology and experimental therapeutics · 2016Article
- Fibromyalgia syndrome in need of effective treatments.The Journal of pharmacology and experimental therapeutics · 2015Review
- Fibromyalgia: A Critical and Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Does aerobic exercise affect the hypothalamic-pituitary-adrenal hormonal response in patients with fibromyalgia syndrome?Journal of physical therapy science · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Mounting evidence suggests fibromyalgia (FM) symptoms are influenced by dysfunction of the hypothalamic-pituitary-hormonal axes (HPHA) and the immune response system. The predominant FM symptoms of widespread pain, fatigue, sleep disturbance, depression, stiffness and exercise intolerance are related to abnormal levels of growth hormone (GH) and are reminiscent of "sickness behavior"; a syndrome initiated by the production of pro-inflammatory cytokines in response to various stressors. Cognizant of the reciprocal relationship between HPHA activity and the immune response system, we hypothesized that serum cytokine levels and FM symptom severity would be higher in FM patients with defective growth hormone response to exhaustive exercise compared to those without. Outpatients with FM (n = 165) underwent a Modified Balke Treadmill Protocol and GH response to exhaustive exercise was measured in peripheral blood samples. Levels of IL-1α, IL-1β, IL-1RA, IL-6, IL-8, IL-10, and TNF-α were measured from stored serum on a subset of 24 participants (12 with and 12 without normal GH response to exhaustive exercise). FM symptom severity was assessed using the Fibromyalgia Impact Questionnaire (FIQ), number of tender points and cumulative myalgic scores. GH dysfunction was associated with increased pain scores on the FIQ (p = 0.024), a greater number of tender points (p = 0.014), higher myalgic scores (p = 0.001) and higher pre-exercise levels of inflammatory cytokines IL-1α (p = 0.021), IL-6 (p = 0.012), and IL-8 (p = 0.004). These results suggest that a defective growth hormone response to exercise may be associated with increased levels of blood cytokines and pain severity in FM patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.