ArticleJournal of biomedicine & biotechnology2010
Maternal-zygotic epistasis and the evolution of genetic diseases.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Runaway coevolution: adaptation to heritable and nonheritable environments.Evolution; international journal of organic evolution · 2014Article
- Identification of maternally-loaded RNA transcripts in unfertilized eggs of Tribolium castaneum.BMC genomics · 2012Article
- Analysis of genetic interactions involving maternal and offspring genotypes at different Loci: power simulation and application to testicular cancer.Genetic epidemiology · 2012Article
- Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.Journal of genetic syndromes & gene therapy · 2012Article
- Gene-gene interaction in maternal and perinatal research.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Many birth defects and genetic diseases are expressed in individuals that do not carry the disease causing alleles. Genetic diseases observed in offspring can be caused by gene expression in mothers and by interactions between gene expression in mothers and offspring. It is not clear whether the underlying pattern of gene expression (maternal versus offspring) affects the incidence of genetic disease. Here we develop a 2-locus population genetic model with epistatic interactions between a maternal gene and a zygotic gene to address this question. We show that maternal effect genes that affect disease susceptibility in offspring persist longer and at higher frequencies in a population than offspring genes with the same effects. We find that specific forms of maternal-zygotic epistasis can maintain disease causing alleles at high frequencies over a range of plausible values. Our findings suggest that the strength and form of epistasis and the underlying pattern of gene expression may greatly influence the prevalence of human genetic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.