ArticleJournal of biomedicine & biotechnology2010
Impaired skeletal muscle repair after ischemia-reperfusion injury in mice.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- Distal Venous Arterialization Modulates Autophagy-Related Markers in Skeletal Muscle in a Rat Hindlimb Ischemia Model.Vascular health and risk management · 2026Article
- Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025Review
- Ultrastructural alterations and mitochondrial dysfunction in skeletal muscle of peripheral artery disease patients: implications for early therapeutic interventions.EXCLI journal · 2024Article
- Contusion concomitant with ischemia injury aggravates skeletal muscle necrosis and hinders muscle functional recovery.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Administration of particulate oxygen generators improves skeletal muscle contractile function after ischemia-reperfusion injury in the rat hindlimb.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Protective Effect of Water-Soluble CInternational journal of molecular sciences · 2021Article
- Insight into molecular profile changes after skeletal muscle contusion using microarray and bioinformatics analyses.Bioscience reports · 2021Article
- Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.Disease models & mechanisms · 2020Article
- Recent Trends in Injury Models to Study Skeletal Muscle Regeneration and Repair.Bioengineering (Basel, Switzerland) · 2020Review
- Lack of miR-378 attenuates muscular dystrophy in mdx mice.JCI insight · 2020Article
- Effects of fasting on isolated murine skeletal muscle contractile function during acute hypoxia.PloS one · 2020Article
- Macrophage Regulation of Muscle Regrowth From Disuse in Aging.Exercise and sport sciences reviews · 2019Review
- Enhanced autophagy alleviates injury during hindlimb ischemia/reperfusion in mice.Experimental and therapeutic medicine · 2019Article
- Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit, Myonuclear-, and Mitochondrial-Domains.Scientific reports · 2019Article
- Article
- Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.Nature biomedical engineering · 2018Article
- Interplay between ROS and Antioxidants during Ischemia-Reperfusion Injuries in Cardiac and Skeletal Muscle.International journal of molecular sciences · 2018Review
- Dexamethasone Protects Against Tourniquet-Induced Acute Ischemia-Reperfusion Injury in Mouse Hindlimb.Frontiers in physiology · 2018Article
- Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.The Journal of clinical investigation · 2017Article
- Effects of prolonged ischemia on human skeletal muscle microcirculation as assessed by near-infrared spectroscopy.Journal of clinical monitoring and computing · 2017Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemia/reperfusion (IR) injury can induce skeletal muscle fibre death and subsequent regeneration. By 14 days, absolute and specific maximal forces and fatigue resistance in ischemic/reperfused soleus muscles were still reduced (-89%, -81%, and -75%, resp.) as compared to control muscles (P < .05). The decrease of these parameters in ischemic/reperfused muscle was much greater than that of myotoxic injured muscles (-12%, -11%, and -19%; P < .05). In addition, at 14 days ischemic/reperfused muscle structure was still abnormal, showing small muscle fibres expressing neonatal myosin heavy chain and large necrotic muscle fibres that were not observed in myotoxin treated muscles. By 56 days, in contrast to myotoxin treated muscles, specific maximal force and muscle weight of the ischemic/reperfused muscles did not fully recover (P < .05). This differential recovery between ischemic/reperfused and myotoxin treated muscles was not related to the differences in the initial cell death, loss of satellite cells after injury, expression of growth factors (IGF1, IGF2..), or capillary density in regenerating muscles. In conclusion, our results demonstrate that IR injury in mice induces long term detrimental effects in skeletal muscles and that the recovery following IR injury was delayed for yet unknown reasons as compared to myotoxic injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.