ArticlePsychosomatic medicine2010
Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.
Article in Psychosomatic medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Factors associated with the risk of cardiovascular disease in family caregivers of people with dementia: a systematic review.The Journal of international medical research · 2020Pooled it
- Relationship Between Chronic Stress Measured by Allostatic Load and Age-Related Macular Degeneration in the All of Us Research Program.American journal of ophthalmology · 2025Article
- It's Not the Genes OR the Environment, It's the Genes AND the Environment!Journal of the American Heart Association · 2021Article
- Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study.African health sciences · 2020Article
- RAB10: an Alzheimer's disease resilience locus and potential drug target.Clinical interventions in aging · 2019Review
- Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors.Lipids in health and disease · 2018Article
- Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk.Lipids in health and disease · 2017Article
- Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.Genetic epidemiology · 2015Article
- Article
- Stressors and common mental disorder in informal carers--an analysis of the English Adult Psychiatric Morbidity Survey 2007.Social science & medicine (1982) · 2014Article
- Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.Lipids in health and disease · 2013Article
- Cross-national differences in the prevalence and correlates of burden among older family caregivers in the World Health Organization World Mental Health (WMH) Surveys.Psychological medicine · 2013Article
- Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.Biological psychology · 2013Article
- Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.Journal of psychiatric research · 2013Article
- Long-Term Impact of Caregiving and Metabolic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research.Open journal of medical psychology · 2013Article
- Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.Biological psychology · 2012Article
- Associations between APOE variants and metabolic traits and the impact of psychological stress.PloS one · 2011Article
- Sleep, type 2 diabetes, dyslipidemia, and hypertension in elderly Alzheimer's caregivers.Archives of gerontology and geriatricsArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations.
methodsThe association between rs769450, rs405509, rs439401, and metabolic traits were analyzed in a U.S. sample of 126 white caregivers of a relative with Alzheimer';s disease or other major dementia and 122 white controls. The associations were analyzed, using multivariate analysis of variance adjusted for age, sex, and medications.
resultsSignificant multivariate interactions were found, using both additive (p = .009) and dominant (p = .047) models between rs439401 (C/T) and caregiver stress in relation to a profile of metabolic variables. Univariate analyses found the TT genotype to be associated with more adverse levels of waist circumference (interaction, p = .026), triglycerides (interaction, p = .001) and high-density lipoprotein cholesterol (interaction, p = .001) among caregivers but with a more favorable profile of these endophenotypes among controls. There were no significant associations or interactions involving the other two single nucleotide polymorphisms.
conclusionThe APOE rs439401 TT genotype is associated with an adverse metabolic profile among chronically stressed individuals compared with individuals not similarly stressed in whom a more favorable profile is expressed. Confirmation of these results in further research would indicate that the TT genotype can be used to identify persons at high risk for CVD when subjected to chronic stress.
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