ArticleClinical cancer research : an official journal of the American Association for Cancer Research2010
A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Blood-Derived Exosomal hTERT mRNA in Patients with Lung Cancer: Characterization and Correlation with Response to Therapy.Biomedicines · 2023Article
- Analysis of MNS16A VNTR polymorphic sequence variations of theCurrent urology · 2021Article
- The MNS16A VNTR polymorphism of the TERT gene in bladder cancer.Turkish journal of urology · 2020Article
- Leukocyte Telomere Length Shortening, hTERT Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic LeukemiaAsian Pacific journal of cancer prevention : APJCP · 2018Article
- MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancer.Oncotarget · 2017Article
- Article
- A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population.BMC medicine · 2011Article
- MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer.Carcinogenesis · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeElevated levels of human telomerase (hTERT) mRNA in tumors is a marker for poorer survival in patients with stage I non-small cell lung cancer (NSCLC). A functional variant of MNS16A-short tandem repeats in hTERT (S allele) is associated with higher expression levels of hTERT mRNA compared with the MNS16A-long (L) allele. It is unknown, however, whether or not the hTERT MNS16A variant genotype predicts survival of NSCLC patients. EXPERIMENTAL
designThe hTERT genotypes of 808 patients with NSCLC were determined by direct PCR with genomic DNA. Overall median survival times were estimated by the life-table method, and the log-rank test was used to test for homogeneity of the survival curves. Both univariate and multivariate Cox proportional hazards models were used to assess the associations between survival time and the hTERT genotype as well as other known risk factors.
resultsThe hTERT variant genotype was not associated with overall survival among the 808 patients. However, among 221 patients with stage I or II NSCLC, the S allele was associated with shorter survival time (P = 0.027, by log-rank test). The adjusted hazard ratios were 1.30 (95% confidence interval, 0.79-2.14; P = 0.310) for the SL-genotype and 2.34 (95% confidence interval, 1.20-4.56, P = 0.012) for the SS-genotype compared with the LL-genotype (P = 0.021 for trend test). These findings were not evident in 587 patients with stage III or IV NSCLC.
conclusionThe functional MNS16A-SS genotype may be a marker for poorer survival in early-stage NSCLC.
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