ArticleCirculation. Heart failure2010
Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model.
Article in Circulation. Heart failure, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure.PLoS computational biology · 2024Article
- Successful Cardiac Resynchronization Therapy Reduces Negative Septal Work in Patient-Specific Models of Dyssynchronous Heart Failure.bioRxiv : the preprint server for biology · 2024Article
- Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.Scientific reports · 2023Article
- Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.Journal of mathematical biology · 2022Article
- Individual variability in animal-specific hemodynamic compensation following myocardial infarction.Journal of molecular and cellular cardiology · 2022Article
- Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium.Journal of biomechanics · 2020Article
- A framework for biomechanics simulations using four-chamber cardiac models.Journal of biomechanics · 2019Article
- Organ-level validation of a cross-bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains.Physiological reports · 2017Article
- Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.Frontiers in physiology · 2017Review
- Biomechanics Simulations Using Cubic Hermite Meshes with Extraordinary Nodes for Isogeometric Cardiac Modeling.Computer aided geometric design · 2016Article
- Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy.Arrhythmia & electrophysiology review · 2015Article
- Fibroblast proliferation alters cardiac excitation conduction and contraction: a computational study.Journal of Zhejiang University. Science. B · 2014Article
- Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study.American journal of physiology. Heart and circulatory physiology · 2013Article
- Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart.American journal of physiology. Heart and circulatory physiology · 2013Article
- A three-dimensional finite element model of human atrial anatomy: new methods for cubic Hermite meshes with extraordinary vertices.Medical image analysis · 2013Article
- Antenatal architecture and activity of the human heart.Interface focus · 2013Article
- A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.Computer methods in biomechanics and biomedical engineering · 2013Article
- Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study.Computational and mathematical methods in medicine · 2013Article
- Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012Article
- An analysis of deformation-dependent electromechanical coupling in the mouse heart.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeart failure (HF) in combination with mechanical dyssynchrony is associated with a high mortality rate. To quantify contractile dysfunction in patients with HF, investigators have proposed several indices of mechanical dyssynchrony, including percentile range of time to peak shortening (WTpeak), circumferential uniformity ratio estimate (CURE), and internal stretch fraction (ISF). The goal of this study was to compare the sensitivity of these indices to 4 major abnormalities responsible for cardiac dysfunction in dyssynchronous HF: dilation, negative inotropy, negative lusitropy, and dyssynchronous activation. METHODS AND
resultsAll combinations of these 4 major abnormalities were included in 3D computational models of ventricular electromechanics. Compared with a nonfailing heart model, ventricles were dilated, inotropy was reduced, twitch duration was prolonged, and activation sequence was changed from normal to left bundle branch block. In the nonfailing heart, CURE, ISF, and WTpeak were 0.97+/-0.004, 0.010+/-0.002, and 78+/-1 milliseconds, respectively. With dilation alone, CURE decreased 2.0+/-0.07%, ISF increased 58+/-47%, and WTpeak increased 31+/-3%. With dyssynchronous activation alone, CURE decreased 15+/-0.6%, ISF increased 14-fold (+/-3), and WTpeak increased 121+/-4%. With the combination of dilation and dyssynchronous activation, CURE decreased 23+/-0.8%, ISF increased 20-fold (+/-5), and WTpeak increased 147+/-5%.
conclusionsDilation and left bundle branch block combined synergistically decreased regional cardiac function. CURE and ISF were sensitive to this combination, but WTpeak was not. CURE and ISF also reflected the relative nonuniform distribution of regional work better than WTpeak. These findings might explain why CURE and ISF are better predictors of reverse remodeling in cardiac resynchronization therapy.
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Registered trials
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