ArticleNucleic acids research2010
Discovering modulators of gene expression.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Inferring Dynamic Regulatory Interaction Graphs from Time Series Data with Perturbations.Proceedings of machine learning research · 2024Article
- Bioinformatics detection of modulators controlling splicing factor-dependent intron retention in the human brain.Human mutation · 2022Article
- Review: Precision Medicine Approaches for Genetic Cardiomyopathy: Targeting Phospholamban R14del.Current heart failure reports · 2022Review
- Differential Co-Expression Analyses Allow the Identification of Critical Signalling Pathways Altered during Tumour Transformation and Progression.International journal of molecular sciences · 2020Review
- Modulator-Dependent RBPs Changes Alternative Splicing Outcomes in Kidney Cancer.Frontiers in genetics · 2020Article
- Modulation of transcriptional activity in brain lower grade glioma by alternative splicing.PeerJ · 2018Article
- A Novel Small Peptide Inhibitor of NFOxidative medicine and cellular longevity · 2018Article
- Large-scale automated machine reading discovers new cancer-driving mechanisms.Database : the journal of biological databases and curation · 2018Article
- Roles of alternative splicing in modulating transcriptional regulation.BMC systems biology · 2017Article
- Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma.Oncotarget · 2016Article
- Inferring genome-wide functional modulatory network: a case study on NF-κB/RelA transcription factor.Journal of computational biology : a journal of computational molecular cell biology · 2015Article
- Correcting positional correlations in Affymetrix® genome chips.Scientific reports · 2015Article
- Kinetically-defined component actions in gene repression.PLoS computational biology · 2015Article
- Modulation of gene expression regulated by the transcription factor NF-κB/RelA.The Journal of biological chemistry · 2014Article
- Inferring transcription factor collaborations in gene regulatory networks.BMC systems biology · 2014Article
- Gene regulation, modulation, and their applications in gene expression data analysis.Advances in bioinformatics · 2013Article
- Pathway-based drug repositioning using causal inference.BMC bioinformatics · 2013Article
- Using biological pathway data with paxtools.PLoS computational biology · 2013Article
- Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.The Journal of biological chemistry · 2012Article
- Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.