Evidence map›Paper›PMID 20466789›Full record

SynthesisBMJ (Clinical research ed.)2010

Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis.

Gemma L Malin, Rachel K Morris, Khalid S Khan

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04703088 (A PROSPECTIVE, RANDOMIZED, DOUBLE-BLINDED STUDY OF THE EFFECT OF A STANDARD DOSE OF INTRAVENOUS ONDANSETRON ON THE EFFECTIVE DOSE IN 50% OF SUBJECTS OF PROPHYLACTIC NOREPINEPHRINE INFUSIONS FOR PREVENTING SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING CESAREAN DELIVERY), which is not on this map. Cited by 138 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04703088 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

A prospective, randomized, double-blinded study of the effect of a standard dose of intravenous ondansetron on the effective dose in 50% of subjects of prophylactic norepinephrine infusions for preventing spinal anesthesia-induced hypotension during cesarean delivery

TypeinterventionalSponsorLaval UniversityRan2021 to 2021Enrolled60ConditionsHypotension, Anesthesia, Adverse Effect, Spinal and Epidural, Cesarean SectionArmsOndansetron 4 MG, 0.9% Saline
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  5. Fetal and Maternal Responses to Dexmedetomidine Intrathecal Application During Cesarean Section: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020
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  15. Comparative Evaluation of Remifentanil and Dexmedetomidine in General Anesthesia for Cesarean Delivery.Medical science monitor : international medical journal of experimental and clinical research · 2015
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Gemma L MalinDepartment of Obstetrics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham. g.l.malin@bham.ac.uk
Rachel K Morris
Khalid S Khan

Funding

Medical Research Council G0700526Medical Research Council RRAK12923
6 · The paper itself

Abstract

objectiveTo evaluate the association between umbilical cord pH at birth and long term outcomes.

designSystematic review and meta-analysis. DATA SOURCES: Medline (1966-August 2008), Embase (1980-August 2008), the Cochrane Library (2008 issue 8), and Medion, without language restrictions; reference lists of selected articles; and contact with authors. STUDY SELECTION: Studies in which cord pH at birth was compared with any neonatal or long term outcome. Cohort and case-control designs were included.

results51 articles totalling 481 753 infants met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that low arterial cord pH was significantly associated with neonatal mortality (odds ratio 16.9, 95% confidence interval 9.7 to 29.5, I(2)=0%), hypoxic ischaemic encephalopathy (13.8, 6.6 to 28.9, I(2)=0%), intraventricular haemorrhage or periventricular leucomalacia (2.9, 2.1 to 4.1, I(2)=0%), and cerebral palsy (2.3, 1.3 to 4.2, I(2)=0%).

conclusionsLow arterial cord pH showed strong, consistent, and temporal associations with clinically important neonatal outcomes that are biologically plausible. These data can be used to inform clinical management and justify the use of arterial cord pH as an important outcome measure alongside neonatal morbidity and mortality in obstetric trials.

Indexed as

AcidosisCerebral PalsyFetal BloodHumansHydrogen-Ion ConcentrationInfant, Low Birth WeightInfant MortalityInfant, NewbornInfant, PrematureInfant, Premature, DiseasesPrognosisRisk Factors

Identifiers

PMID20466789
PMCPMC2869402

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.