ArticleThe Journal of clinical endocrinology and metabolism2010
Runs of homozygosity identify a recessive locus 12q21.31 for human adult height.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Integrative multi-omics analysis of growth plate regulation underlying body size in miniature pigs.Communications biology · 2026Article
- The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.bioRxiv : the preprint server for biology · 2025Article
- Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.eLife · 2024Article
- Genetic ancestry plays a central role in population pharmacogenomics.Communications biology · 2021Article
- Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank.medRxiv : the preprint server for health sciences · 2020Article
- A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.Frontiers in endocrinology · 2019Article
- Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia.Frontiers in genetics · 2019Article
- Comparison of multi-lineage differentiation of hiPSCs reveals novel miRNAs that regulate lineage specification.Scientific reports · 2018Article
- Runs of homozygosity: windows into population history and trait architecture.Nature reviews. Genetics · 2018Review
- Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females.Journal of Cancer · 2018Article
- Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.BMC genomics · 2017Article
- GARLIC: Genomic Autozygosity Regions Likelihood-based Inference and Classification.Bioinformatics (Oxford, England) · 2017Article
- Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans.Genetics · 2016Article
- Evidence of Inbreeding in Hodgkin Lymphoma.PloS one · 2016Article
- Inbreeding and homozygosity in breast cancer survival.Scientific reports · 2015Article
- Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Whole-genome resequencing of Hanwoo (Korean cattle) and insight into regions of homozygosity.BMC genomics · 2013Article
- A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.Human genetics · 2012Article
- Article
- Human genetics and genomics a decade after the release of the draft sequence of the human genome.Human genomics · 2011Review
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8 authors.
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Abstract
backgroundRuns of homozygosity (ROHs) have recently been proposed to have potential recessive significance for complex traits. Human adult height is a classic complex trait with heritability estimated up to 90%, and recessive loci that contribute to adult height variation have been identified.
methodsUsing the Affymetrix 500K array set, we performed a genome-wide ROHs analysis to identify genetic loci for adult height in a discovery sample including 998 unrelated Caucasian subjects from the midwest United States. For the significant ROHs identified, we replicated these findings in a family-based sample of 8385 Caucasian subjects from the Framingham Heart Study (FHS).
resultsOur results revealed one ROH, located in 12q21.31, that had a strong association with adult height variation both in the discovery (P=6.69x10(-6)) and replication samples (P=5.40x10(-5)). We further validated the presence of this ROH using the HapMap sample.
conclusionOur findings open a new avenue for identifying loci with recessive contributions to adult height variation. Further molecular and functional studies are needed to explore and clarify the potential mechanism.
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