ArticleCerebral cortex (New York, N.Y. : 1991)2011
Gonadectomy and hormone replacement affects in vivo basal extracellular dopamine levels in the prefrontal cortex but not motor cortex of adult male rats.
Article in Cerebral cortex (New York, N.Y. : 1991), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Gonadal hormones and impulsivity facets: moderating roles of cortisol and anxiety.Frontiers in psychology · 2026Article
- Neurosteroids and the mesocorticolimbic system.Neuroscience and biobehavioral reviews · 2023Review
- Sex differences in VTA GABA transmission and plasticity during opioid withdrawal.Scientific reports · 2023Article
- Menopausal hormone therapy and risk of dementia: health insurance database in South Korea-based retrospective cohort study.Frontiers in aging neuroscience · 2023Article
- A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala.Biology of sex differences · 2022Article
- Coming of age in the frontal cortex: The role of puberty in cortical maturation.Seminars in cell & developmental biology · 2021Review
- HIV-Associated Apathy/Depression and Neurocognitive Impairments Reflect Persistent Dopamine Deficits.Cells · 2021Review
- Dopamine Modulation of Motor and Sensory Cortical Plasticity among Vertebrates.Integrative and comparative biology · 2021Review
- The effects of early life stress on motivated behaviors: A role for gonadal hormones.Neuroscience and biobehavioral reviews · 2020Review
- Sex differences in incentive motivation and the relationship to the development and maintenance of alcohol use disorders.Physiology & behavior · 2019Review
- Anabolic-androgenic steroids (AAS) increase sensitivity to uncertainty by inhibition of dopamine D1 and D2 receptors.Psychopharmacology · 2018Article
- Testosterone boosts physical activity in male mice via dopaminergic pathways.Scientific reports · 2018Article
- Androgen Regulation of the Mesocorticolimbic System and Executive Function.Frontiers in endocrinology · 2018Review
- Sexual congruency in the connectome and translatome of VTA dopamine neurons.Scientific reports · 2017Article
- Article
- Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats.Neuroscience · 2015Article
- Sex-dependent effects on tasks assessing reinforcement learning and interference inhibition.Frontiers in psychology · 2015Article
- Effects of chronic REM sleep restriction on D1 receptor and related signal pathways in rat prefrontal cortex.BioMed research international · 2015Article
- Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis.Neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Gonadectomy in adult male rats is known to impair performance on dopamine (DA)-dependent prefrontal cortical tasks and selectively dysregulate end points in the mesoprefrontal DA system including axon density. In this study, in vivo microdialysis and high-pressure liquid chromatography were used to determine whether short (4 day)- and/or long-term (28 day) gonadectomy and hormone replacement might also influence the more functionally relevant metric of basal extracellular DA level/tone. Assessments in medial prefrontal cortex revealed that DA levels were significantly lower than control in 4-day gonadectomized rats and similar to control in 4-day gonadectomized animals supplemented with both testosterone and estradiol. Among the long-term treatment groups, DA levels were significantly higher than control in gonadectomized rats and gonadectomized rats given estradiol but were similar to control in rats given testosterone. In contrast, extracellular DA levels measured in motor cortex were unaffected by long- or short-term gonadectomy. The effects of gonadectomy and hormone replacement on prefrontal cortical DA levels observed here parallel previously identified effects on prefrontal DA axon density and could represent hormone actions relevant to the modulation of DA-dependent prefrontal cortical function and perhaps its dysfunction in disorders such as schizophrenia, attention deficit hyperactivity disorder, and autism where males are disproportionately affected relative to females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.