ArticleHuman molecular genetics2010
Refining the association of MHC with multiple sclerosis in African Americans.
Article in Human molecular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review.Frontiers in immunology · 2023Pooled it
- Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing.Scientific reports · 2024Article
- Article
- Development of Recombinant Oncolytic rVSV-mIL12-mGMCSF for Cancer Immunotherapy.International journal of molecular sciences · 2023Article
- High-resolution HLA class II sequencing of Swedish multiple sclerosis patients.International journal of immunogenetics · 2022Article
- Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans.Multiple sclerosis and related disorders · 2021Article
- Association of HLA-DR2-Related Haplotype (HLA-DRB5*01-DRB1*1501-DQB1*0602) in Patients with Multiple Sclerosis in Khuzestan Province.Iranian journal of child neurology · 2021Article
- Article
- The single nucleotide polymorphism site of aquaporin-4 gene in patients with neuromyelitis optica.Experimental and therapeutic medicine · 2017Article
- Multiple sclerosis-like diagnosis as a complication of previously treated malaria in an iron and vitamin D deficient Nigerian patient.Metabolic brain disease · 2016Article
- MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity.BMC neurology · 2015Article
- Biomarker Detection in Association Studies: Modeling SNPs Simultaneously via Logistic ANOVA.Journal of the American Statistical Association · 2014Article
- HLA diversity in the 1000 genomes dataset.PloS one · 2014Article
- Article
- Progress in multiple sclerosis genetics.Current genomics · 2012Article
- The genetics of multiple sclerosis: an up-to-date review.Immunological reviews · 2012Review
- Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populations.PloS one · 2012Article
- SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients.Genes and immunity · 2011Article
- ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.American journal of respiratory and critical care medicine · 2011Article
- Genetic determinants of HSP70 gene expression following heat shock.Human molecular genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system mediated by autoimmune and neurodegenerative pathogenic mechanisms. Multiple genes account for its moderate heritability, but the only genetic region shown to have a large replicable effect on MS susceptibility is the major histocompatibility complex (MHC). Strong linkage disequilibrium (LD) across the MHC has made it difficult to fully characterize individual genetic contributions of this region to MS risk in previous studies. African Americans are at a lower risk for MS when compared with northern Europeans and Americans of European descent, but greater haplotypic diversity and distinct patterns of LD suggest that this population may be particularly informative for fine-mapping efforts. To examine the role of the MHC in African American MS, a case-control association study was performed with 499 African American MS patients and 750 African American controls that were genotyped for 6040 MHC region single nucleotide polymorphisms (SNPs). A replication data set consisting of 451 African American patients and 718 African American controls was genotyped for selected SNPs. Two MHC class II SNPs, rs2647040 and rs3135021, were significant in the replication cohort and partially tagged DRB1*15 alleles. Surprisingly, in comparison to similar studies of individuals of European descent, the MHC seems to play a smaller role in MS susceptibility in African Americans, consistent with pervasive genetic heterogeneity across ancestral groups, and may explain the difference in MS susceptibility between African Americans and individuals of European descent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.