ArticleMolecular and cellular biology1991
Protein synthesis requirements for nuclear division, cytokinesis, and cell separation in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Cytokinesis regulators as potential diagnostic and therapeutic biomarkers for human hepatocellular carcinoma.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- ADP-ribosylation of translation elongation factor 2 by diphtheria toxin in yeast inhibits translation and cell separation.The Journal of biological chemistry · 2013Article
- The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.PLoS genetics · 2013Article
- Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.PLoS genetics · 2012Article
- Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.The Journal of cell biology · 2011Article
- Nuclear actin: A key player in extracellular matrix-nucleus communication.Communicative & integrative biology · 2011Article
- Metabolic status rather than cell cycle signals control quiescence entry and exit.The Journal of cell biology · 2011Article
- Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing.Nature cell biology · 2010Article
- Article
- TOR signaling is a determinant of cell survival in response to DNA damage.Molecular and cellular biology · 2007Article
- 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs.Molecular and cellular biology · 2004Article
- Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.Molecular biology of the cell · 2004Article
- Article
- Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae.BMC genetics · 2002Article
- CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E.The Biochemical journal · 1999Article
- Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.Molecular and cellular biology · 1998Article
- The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast.The EMBO journal · 1997Article
- Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.The EMBO journal · 1997Article
- Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.Molecular and cellular biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protein synthesis inhibitors have often been used to identify regulatory steps in cell division. We used cell division cycle mutants of the yeast Saccharomyces cerevisiae and two chemical inhibitors of translation to investigate the requirements for protein synthesis for completing landmark events after the G1 phase of the cell cycle. We show, using cdc2, cdc6, cdc7, cdc8, cdc17 (38 degrees C), and cdc21 (also named tmp1) mutants, that cells arrested in S phase complete DNA synthesis but cannot complete nuclear division if protein synthesis is inhibited. In contrast, we show, using cdc16, cdc17 (36 degrees C), cdc20, cdc23, and nocodazole treatment, that cells that arrest in the G2 stage complete nuclear division in the absence of protein synthesis. Protein synthesis is required late in the cell cycle to complete cytokinesis and cell separation. These studies show that there are requirements for protein synthesis in the cell cycle, after G1, that are restricted to two discrete intervals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.