ReviewCurrent opinion in cell biology2010
3D shortcuts to gene regulation.
Review in Current opinion in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis.The FEBS journal · 2017Article
- Cajal body function in genome organization and transcriptome diversity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes.American journal of physiology. Endocrinology and metabolism · 2016Article
- Spatial re-organization of myogenic regulatory sequences temporally controls gene expression.Nucleic acids research · 2015Article
- Quantitative analysis of genomic element interactions by molecular colony technique.Nucleic acids research · 2014Article
- Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor.Molecular and cellular endocrinology · 2013Review
- Cycles in spatial and temporal chromosomal organization driven by the circadian clock.Nature structural & molecular biology · 2013Article
- Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.Endocrine reviews · 2013Review
- Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.Genome research · 2013Article
- Complex dynamics of transcription regulation.Biochimica et biophysica acta · 2012Review
- Impact of chromatin structure on PR signaling: transition from local to global analysis.Molecular and cellular endocrinology · 2012Review
- Article
- Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- More to Hi-C than meets the eye.Nature genetics · 2011Article
- Gene-specific transcription activation via long-range allosteric shape-shifting.The Biochemical journal · 2011Review
- Epigenetic regulation of retinal development and disease.Journal of ocular biology, diseases, and informatics · 2011Article
- Control of nuclear receptor function by local chromatin structure.The FEBS journal · 2011Review
- Chromatin: constructing the big picture.The EMBO journal · 2011Review
- Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements.Genome research · 2011Article
- Polycomb targets seek closest neighbours.PLoS genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent technologies have allowed high-resolution genome-wide binding profiles of numerous transcription factors and other proteins. A widespread observation has emerged from studies in diverse mammalian systems: most binding events are located at great distances from gene promoters. It is becoming apparent that the traditional one-dimensional view of gene regulation via the proximal cis regulatory elements is over-simplified. True proximity and functional relevance can be revealed by studying the three-dimensional structure of the genome packaged inside the nucleus. Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.