ArticleEpilepsy research2010
Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy.
Article in Epilepsy research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- A Review of the Multi-Systemic Complications of a Ketogenic Diet in Children and Infants with Epilepsy.Children (Basel, Switzerland) · 2022Review
- Anticonvulsant Effects of Carbonic Anhydrase Inhibitors: The Enigmatic Link Between Carbonic Anhydrases and Electrical Activity of the Brain.Neurochemical research · 2021Review
- Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus.Neurology. Clinical practice · 2021Review
- Incidence and Characteristics of Kidney Stones in Patients on Ketogenic Diet: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2021Article
- Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group.Epilepsia open · 2020Article
- Article
- Low-Carbohydrate and Very-Low-Carbohydrate Diets in Patients With Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2020Article
- Drug-Induced Urolithiasis in Pediatric Patients.Paediatric drugs · 2019Review
- Current Perspectives On The Role Of The Ketogenic Diet In Epilepsy Management.Neuropsychiatric disease and treatment · 2019Review
- Ketogenic Diets for Adult Neurological Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group.Epilepsia open · 2018Article
- Risk factors for urolithiasis in gastrostomy tube fed children: a case-control study.Pediatrics · 2013Article
- Safety and tolerability of antiepileptic drug treatment in children with epilepsy.Drug safety · 2012Review
- Anticonvulsant-induced rickets and nephrocalcinosis.BMJ case reports · 2012Article
- The safety and tolerability of newer antiepileptic drugs in children and adolescents.Journal of central nervous system disease · 2012Article
- Ketogenic Diet: It Has a Role in Our Armamentarium of Treatment of Refractory Seizures.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Children with refractory epilepsy who are co-treated with the ketogenic diet (KD) and carbonic anhydrase inhibitor (CA-I) anti-epileptic medications including topiramate (TPM) and zonisamide (ZNS) are at risk for urolithiasis. Retrospective chart review of all children treated with ketogenic therapy at our institution was performed in order to estimate the minimal risk of developing signs or symptoms of stone disease. Children (N=93) were classified into groups according to KD+/-CA-I co-therapy. Fourteen patients had occult hematuria or worse, including 6 with radiologically confirmed stones. Three of 6 calculi developed in the KD+ZNS group of 17 patients who were co-treated for a cumulative total of 97 months (3.1 stones per 100 patient months). One confirmed stone was in the KD+TPM group of 22 children who were co-treated for a cumulative total of 263 months (0.4 stones per 100 patient months). All six patients had at least three of five biochemical risk factors including metabolic acidosis, concentrated urine, acid urine, hypercalciuria and hypocitraturia. Standard of care interventions to minimize hypercalciuria, crystalluria and stone formation used routinely by pediatric nephrologists should also be prescribed by neurologists treating patients with combination anti-epileptic therapy. Non-fasting KD initiation, fluid liberalization, potassium citrate prophylaxis as well as regular laboratory surveillance are indicated in this high risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.