Evidence map›Paper›PMID 20466277›Full record

ReviewInfectious disease clinics of North America2010

Antiviral drug resistance: mechanisms and clinical implications.

Lynne Strasfeld, Sunwen Chou

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. The Redesign of the Molecular Scaffold of Viral Ion Channel Blockers.Computational and structural biotechnology journal · 2026
    Article
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lynne StrasfeldDivision of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, mail code L457, Portland, OR 97239, USA. strasfel@ohsu.edu
Sunwen Chou

Funding

ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUSR01AI039938 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI CHOU, SUNWEN · 1996 to 2013
$3.4M
NIAID NIH HHS AI39938NIAID NIH HHS R01 AI039938
6 · The paper itself

Abstract

Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.

Indexed as

Drug Resistance, ViralImmunocompromised HostAntiviral AgentsHumansNeoplasmsTransplantationVirus DiseasesVirusesAntiviral Agents

Identifiers

PMID20466277
PMCPMC2871161

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.