Evidence map›Paper›PMID 20466088›Full record

ArticleBone2010

Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study.

Julie M Cousins, Moira A Petit, Misti L Paudel, Brent C Taylor, Julie M Hughes, Jane A Cauley, Joseph M Zmuda, Peggy M Cawthon, Kristine E Ensrud, Osteoporotic Fractures in Men (MrOS) Study Group

Registry-linked trialAbstract read
In one paragraph

Article in Bone, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02421393 (Study to Weigh the Effect of Exercise Training on BONE Quality and Strength), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02421393 nacompletednot on this mapstarted 2018, after this paper: background citation

Study to Weigh the Effect of Exercise Training on BONE Quality and Strength (SWEET-BONE) in Type 2 Diabetes: an Exercise Intervention Program for Reducing the Risk of Fractures

TypeinterventionalSponsorMetabolic Fitness Association, ItalyRan2018 to 2024Enrolled200ConditionsType 2 DiabetesArmssupervised exercise training
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Changes in Objectively Measured Physical Activity Are Associated With Perceived Physical and Mental Fatigability in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. High-Intensity Physical Activity with High Serum Vitamin D Levels is Associated with a Low Prevalence of Osteopenia and Osteoporosis: A Population-Based Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Knee strength, power and stair performance of the elderly 5 years after unicompartmental knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018
    Article
  17. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Julie M CousinsSchool of Kinesiology, Laboratory for Musculoskeletal Health, University of Minnesota, Minneapolis, MN 55455, USA.
Moira A Petit
Misti L Paudel
Brent C Taylor
Julie M Hughes
Jane A Cauley
Joseph M Zmuda
Peggy M Cawthon
Kristine E Ensrud
Osteoporotic Fractures in Men (MrOS) Study Group
University of Minnesota · USCalifornia Pacific Medical Center · USVeterans Health Administration · USUniversity of Pittsburgh · US

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
OSTEOPOROTIC FRACTURES IN MENU01AG018197 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON · 1999 to 2011
$12.7M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Osteoporotic Fractures in Men: MrOS Renewal-PortlandU01AR045647 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 1999 to 2011
$6.7M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Osteoporotic Fractures in Men - Renewal: PittsburghU01AR045654 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 1999 to 2011
$5.1M
OSTEOPOROTIC FRACTURES IN MENU01AR045614 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1999 to 2011
$4.0M
Osteoporotic Fractures in MenU01AR045583 · NIAMS · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 1999 to 2011
$4.0M
Osteoporotic Fractures in Men - MrOS RenewalU01AR045580 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1999 to 2011
$3.9M
Osteoporotic Fractures in Men- MrOS Renewal - BirminghamU01AR045632 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 1999 to 2011
$3.6M
NCRR NIH HHS UL1 RR024140NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045614NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR045654NIAMS NIH HHS U01 AR066160NIAMS NIH HHS U01 AR45580NIAMS NIH HHS U01 AR45583NIAMS NIH HHS U01 AR45614NIAMS NIH HHS U01 AR45632NIAMS NIH HHS U01 AR45647NIAMS NIH HHS U01 AR45654NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U01-AG027810NIA NIH HHS U01 AG18197
6 · The paper itself

Abstract

The purpose of these analyses was to explore whether physical activity score, leg power or grip strength were associated with tibia and radius estimates of bone strength, cortical density, or total bone area. Peripheral quantitative computed tomography (pQCT) was used to compare tibial and radial bone volumetric density (vBMD, mg/cm(3)), total (ToA, mm(2)) and cortical (CoA, mm(2)) bone area, and estimates of bone compressive strength (bone strength index, BSI) and bending strength (polar strength strain index, SSIp) in a subset (n=1171) of men (> or = 65 years) who participated in the multi-site Osteoporotic Fractures in Men (MrOS) study. Physical activity was assessed by questionnaire (PASE), leg power by Nottingham Power Rig, and grip strength by a hand-held Dynamometer. Participants were categorized into quartiles of PASE, grip strength or leg power. The model was adjusted for age, race, clinic, weight, and limb length. In the tibia, BSI (+7%) and SSIp (+4%) were highest in the most active physically quartile compared to the least active (p<0.05). At the 4% site of the tibia, men with the greatest leg power had both greater ToA (+5%, p<0.001) and BSI (+5.3%, p=0.086) compared to men with the least leg power. At the 66% site of the tibia, the men with the highest leg power, compared to the men with the lowest leg power, had greater ToA (+3%, p=0.045) SSIp (+5%, p=0.008). Similar results were found at both the distal and midshaft of the radius. The findings of this study suggest the importance of maintaining levels of physical activity and muscle strength in older men to prevent bone fragility.

Indexed as

Absorptiometry, PhotonAgedBone and BonesConfidence IntervalsFractures, BoneHand StrengthHumansMaleMotor ActivityMuscle StrengthOsteoporosisRadiusTibia

Identifiers

PMID20466088
PMCPMC3073372
OpenAlexW2042485053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.