ReviewMolecular pain2010
A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging.
Review in Molecular pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 3 syntheses or guidelines pooled it, 320 citations in OpenAlex.
- Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Pooled it
- Functional changes of default mode network and structural alterations of gray matter in patients with irritable bowel syndrome: a meta-analysis of whole-brain studies.Frontiers in neuroscience · 2023Pooled it
- Coordinate-based (ALE) meta-analysis of acupuncture for musculoskeletal pain.Frontiers in neuroscience · 2022Pooled it
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain.Scientific reports · 2018Trial
- Opioid modulation of resting-state anterior cingulate cortex functional connectivity.Journal of psychopharmacology (Oxford, England) · 2014Trial
- Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI.PloS one · 2013Trial
- Trial
- Advanced Brain Ageing Associated with Migraine and Post-Traumatic Headache: A Deep Learning Study.Neurology open access · 2026Article
- Pain in Parkinson's disease: bridging pathophysiology, clinical features, and personalized management.The journal of headache and pain · 2026Review
- Chronic Ocular Surface Pain: A Missing Member of the Chronic Overlapping Pain Conditions?Drugs · 2026Review
- Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.Brain topography · 2026Article
- Prediction of Postherpetic Neuralgia in Patients with Acute and Subacute Herpetic Neuralgia Using Structural Magnetic Resonance Imaging: A Retrospective Study.Pain and therapy · 2026Article
- Pain and sensory abnormalities in prodromal and early Parkinson's disease: mechanisms, assessment, and clinical implications.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application.BMC medical imaging · 2025Article
- Sex-specific genetics underlie increased chronic pain risk in women: decoding the genetic architecture of chronic pain. Comment on Br J Anaesth 2025; 135: 401-5.British journal of anaesthesia · 2025Article
- Article
- Depression and anxiety symptom networks in hemorrhoid patients: evidence from the UK biobank.BMC psychology · 2025Article
- Exploring Heterogeneity in Vestibular Migraine Using Individualized Differential Structural Covariance Network Analysis.CNS neuroscience & therapeutics · 2025Article
- Sex-specific genetics underlie increased chronic pain risk in women: genome-wide association studies from the UK Biobank.British journal of anaesthesia · 2025Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.