ArticleDiabetology & metabolic syndrome2010
Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats.
Article in Diabetology & metabolic syndrome, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Targeting the PI3K/Akt/mTOR and Nrf2 signaling axis with berberine: a novel strategy for attenuating diabetic cardiomyopathy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Effect ofFood science & nutrition · 2026Article
- The Potential of Ozone Therapy as an Adjunct to Periodontal Treatment in Diabetes Mellitus: A Biomarkers Scoping Review.Current diabetes reviews · 2026Article
- The Effect of Ozone on Kidney and Liver Tissues in the Treatment of Sepsis Caused by Cecal Perforation in Diabetic Mice.Drug design, development and therapy · 2025Article
- The Protective Role of Ozone Therapy in Kidney Disease: A Review.Life (Basel, Switzerland) · 2023Review
- Intraperitoneal ozone injection prevents REM sleep deprivation - induced spatial learning and memory deficits by suppressing the expression ofIranian journal of basic medical sciences · 2022Article
- The effects of ozone and melatonin on busulfan-induced testicular damage in mice.JBRA assisted reproduction · 2021Article
- Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders.Ageing research reviews · 2020Review
- Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry.Diabetologia · 2018Article
- Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations.Cell communication and signaling : CCS · 2017Article
- The effects of ozone therapy on caspase pathways, TNF-α, and HIF-1α in diabetic nephropathy.International urology and nephrology · 2016Article
- Daily Oxygen/O₃ Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise.Oxidative medicine and cellular longevity · 2015Article
- Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats.Chinese journal of integrative medicine · 2014Article
- Antioxidant Enzymes and Lipid Peroxidation in Type 2 Diabetes Mellitus Patients with and without Nephropathy.North American journal of medical sciences · 2013Article
- Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?Medical gas research · 2011Article
- Ozone acting on human blood yields a hormetic dose-response relationship.Journal of translational medicine · 2011Article
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3 authors.
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Abstract
backgroundSeveral complications of diabetes mellitus (DM) e.g. nephropathy (DN) have been linked to oxidative stress. Ozone, by means of oxidative preconditioning, may exert its protective effects on DN.
aimThe aim of the present work is to study the possible role of ozone therapy in ameliorating oxidative stress and inducing renal antioxidant defence in streptozotocin (STZ)-induced diabetic rats.
methodsSix groups (n = 10) of male Sprague Dawley rats were used as follows: Group C: Control group. Group O: Ozone group, in which animals received ozone intraperitoneally (i.p.) (1.1 mg/kg). Group D: Diabetic group, in which DM was induced by single i.p. injections of streptozotocin (STZ). Group DI: Similar to group D but animals also received subcutaneous (SC) insulin (0.75 IU/100 gm BW.). Group DO: In which diabetic rats received the same dose of ozone, 48 h after induction of diabetes. Group DIO, in which diabetic rats received the same doses of insulin and ozone, respectively. All animals received daily treatment for six weeks. At the end of the study period (6 weeks), blood pressure, blood glycosylated hemoglobin (HbA1c), serum creatinine, blood urea nitrogen (BUN), kidney tissue levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GPx), aldose reductase (AR) activities and malondialdehyde (MDA) concentration were measured.
resultsInduction of DM in rats significantly elevated blood pressure, HbA1c, BUN, creatinine and renal tissue levels of MDA and AR while significantly reducing SOD, CAT and GPx activities. Either Insulin or ozone therapy significantly reversed the effects of DM on all parameters; in combination (DIO group), they caused significant improvements in all parameters in comparison to each alone.
conclusionsOzone administration in conjunction with insulin in DM rats reduces oxidative stress markers and improves renal antioxidant enzyme activity which highlights its potential uses in the regimen for treatment of diabetic patients.
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