Trial reportJournal of periodontal research2010
Systemic endotoxin levels in chronic indolent periodontal infections.
Trial report in Journal of periodontal research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of stannous fluoride dentifrice on gingival health and oxidative stress markers: a prospective clinical trial.BMC oral health · 2024Trial
- Curriculum Gaps in Periodontal Knowledge Among Medical Students: A Cross-Sectional Study.European journal of dental education : official journal of the Association for Dental Education in Europe · 2026Article
- Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients.Open medicine (Warsaw, Poland) · 2024Review
- Blood Biomarkers and Serologic Immunological Profiles Related to Periodontitis in Abdominal Aortic Aneurysm Patients.Frontiers in cellular and infection microbiology · 2021Article
- Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice.Frontiers in immunology · 2021Article
- Bacterial supernatants elevate glucose-dependent insulin secretion in rat pancreatic INS-1 line and islet β-cells via PI3K/AKT signaling.Molecular and cellular biochemistry · 2019Article
- Association between periodontal pathogens and systemic disease.Biomedical journal · 2019Review
- Cerebral microbleeds in a neonatal rat model.PloS one · 2017Article
- The association of periodontal disease with kidney function decline: a longitudinal retrospective analysis of the MrOS dental study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Observational
- Management of diabolical diabetes mellitus and periodontitis nexus: Are we doing enough?World journal of diabetes · 2016Review
- Association Between Periodontal Disease and Kidney Function Decline in African Americans: The Jackson Heart Study.Journal of periodontology · 2015Article
- The association of periodontitis and metabolic syndrome.Dental research journal · 2014Review
- Hyperlipidemia modifies innate immune responses to lipopolysaccharide via the TLR-NF-κB signaling pathway.Inflammation · 2013Article
- Periodontitis and insulin resistance: casual or causal relationship?Diabetes & metabolism journal · 2012Article
- Chronic kidney disease and use of dental services in a United States public healthcare system: a retrospective cohort study.BMC nephrology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivePeriodontal disease has been linked with an increased risk of various systemic diseases. A plausible biologic explanation for this link includes the opportunity for oral pathogens to translocate to the circulation as a result of breakdown in integrity of the oral epithelium. This study refined a methodology used to detect endotoxin activity in the serum of subjects with indolent periodontal infections. MATERIAL AND
methodsThe QCL Kinetic Chromogenic Assay (Cambrex) is a kinetic measure of endotoxin activity. Sera from 211 pregnant women with periodontitis enrolled in the Obstetrics and Periodontal Therapy Trial were used to develop the assay further and to evaluate the detection of endotoxin activity that might accompany a low-level bacteremia in chronic periodontitis.
resultsWe optimized the system to increase the sensitivity and reproducibility of the assay. The refined system was able to detect endotoxin activity in serum at > 0.0125 EU/mL. At baseline (13-16 wk of gestation), 35.5% of the women were positive for endotoxin activity (1.62 +/- 2.21; range: 0.38-15 EU/mL).
conclusionThis report describes a sensitive measure of endotoxin activity in serum. The procedure allowed us to document levels of this microbial virulence factor in serum of individuals with indolent infections such as periodontal disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.