ArticleCurrent eye research2010
Metabolic responses to light in monkey photoreceptors.
Article in Current eye research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Optical coherence tomography angiography parameters after cataract surgery.International ophthalmology · 2023Article
- Variation and heritability of retinal cone ratios in a free-ranging population of rhesus macaques.Evolution; international journal of organic evolution · 2022Article
- Extracellular KExperimental eye research · 2022Article
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Apoptosis inducing factor deficiency causes retinal photoreceptor degeneration. The protective role of the redox compound methylene blue.Redox biology · 2019Article
- Retinal tissue oxygen tension and consumption during light flicker stimulation in rat.Experimental eye research · 2018Article
- Do photoreceptor cells cause the development of retinal vascular disease?Vision research · 2017Review
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Human Pathophysiological Adaptations to the Space Environment.Frontiers in physiology · 2017Review
- Spare the rods and spoil the retina: revisited.Eye (London, England) · 2016Review
- Photoreceptors in diabetic retinopathy.Journal of diabetes investigation · 2015Review
- Oxygen consumption and distribution in the Long-Evans rat retina.Experimental eye research · 2012Article
- New concept: treating nonproliferative diabetic retinopathy with light adaptation of rods during sleep.Eye (London, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTransient changes in intraretinal oxygen tension (PO(2)) in response to light stimuli were studied in order to understand the dynamics of light-evoked changes in photoreceptor oxidative metabolism.
methodsPO(2) changes during illumination were recorded by double-barreled microelectrodes in the outer part of the perifoveal retina in five macaques (Rhesus and Cynomolgus) and were fitted to a single exponential equation to obtain the time constant (tau) and maximum PO(2) change.
resultsAt the onset of light, PO(2) increased at all illuminations in all animals. The magnitude of the light-evoked PO(2) change increased with increasing illumination over 3-4 log units but decreased in all animals at the maximum illumination. The median time constant of the PO(2) change (tau) was 26 sec and was not correlated with illumination. The time constant for the return to darkness was similar for illuminations below rod saturation. Since O(2) diffusion is fast over the short distance from the choroid to the inner segments, tau reflects the time course of the underlying change in oxidative metabolism.
conclusionsPrevious results suggested that two competing processes influence the change in photoreceptor oxidative metabolism with light, Na(+)/K(+) pumping and cyclic guanosine monophosphate (cGMP) turnover. Because a single exponential fitted the PO(2) data, it appears that these processes have time constants that differ by no more than a few seconds in primate. In monkeys, tau is longer than previously reported values for cat and rat. Longer time constants are related to larger photoreceptor volume, possibly because metabolic rate is controlled by intracellular Na(+), and a change in intracellular Na(+) after the onset of illumination occurs more slowly in larger photoreceptors. The "metabolic threshold" illumination that reduced oxygen consumption by about 10% is approximately the same as the illumination that closes 10% of the light-dependent cation channels that are open in the dark.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.