Trial reportPharmaceutical research2011
In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography.
Trial report in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 127 citations in OpenAlex.
- Innate local response and tissue recovery following application of high density microarray patches to human skin.Scientific reports · 2020Trial
- Advancing intradermal vaccine delivery: Focus on hollow microneedles and skin models.Human vaccines & immunotherapeutics · 2026Review
- In vitro Evaluation of Hydroxypropyl-β-cyclodextrin Effects on Rhein Flux Across Microneedle-pretreated Skin.AAPS PharmSciTech · 2026Article
- Optimization of LCD-Based 3D Printing for the Development of Clotrimazole-Coated Microneedle Systems.Materials (Basel, Switzerland) · 2025Article
- Characterising Skin Electrical Impedance Using Tape Stripping Methods: A Bioelectrical Study of a Porcine Model.Cureus · 2024Article
- Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.Annals of dermatology · 2024Article
- Polymeric Microneedles Enhance Transdermal Delivery of Therapeutics.Pharmaceutics · 2024Article
- A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution.Pharmaceutical research · 2024Article
- Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery.Biomedicines · 2023Review
- Three Dimensional Printing and Its Applications Focusing on Microneedles for Drug Delivery.Pharmaceutics · 2023Review
- Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.Advanced healthcare materials · 2023Article
- Hydrogel-forming microarray patch mediated transdermal delivery of tetracycline hydrochloride.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Microneedle-based insulin transdermal delivery system: current status and translation challenges.Drug delivery and translational research · 2022Review
- A 3D-printed transepidermal microprojection array for human skin microbiome sampling.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- 3D Printing-A "Touch-Button" Approach to Manufacture Microneedles for Transdermal Drug Delivery.Pharmaceutics · 2021Review
- Challenges and opportunities for small volumes delivery into the skin.Biomicrofluidics · 2021Article
- Current trends in polymer microneedle for transdermal drug delivery.International journal of pharmaceutics · 2020Review
- Delivery Strategies for Skin: Comparison of Nanoliter Jets, Needles and Topical Solutions.Annals of biomedical engineering · 2020Article
- Laser facilitates week-long sustained transdermal drug delivery at high doses.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Recent advances of microneedles for biomedical applications: drug delivery and beyond.Acta pharmaceutica Sinica. B · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeTo gather sub-surface in situ images of microneedle-treated human skin, in vivo, using optical coherence tomography (OCT). This is the first study to utilise OCT to investigate the architectural changes that are induced in skin following microneedle application.
methodsSteel, silicon and polymer microneedle devices, with different microneedle arrangements and morphologies, were applied to two anatomical sites in human volunteers following appropriate ethical approval. A state-of-the-art ultrahigh resolution OCT imaging system operating at 800 nm wavelength and <3 µm effective axial resolution was used to visualise the microneedle-treated area during insertion and/or following removal of the device, without any tissue processing.
resultsTransverse images of a microneedle device, in situ, were captured by the OCT system and suggest that the stratified skin tissue is compressed during microneedle application. Following removal of the device, the created microchannels collapse within the in vivo environment and, therefore, for all studied devices, microconduit dimensions are markedly smaller than the microneedle dimensions.
conclusionsMicrochannels created in the upper skin layers by microneedles are less invasive than previous histology predicts. OCT has the potential to play a highly influential role in the future development of microneedle devices and other transdermal delivery systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.