Evidence map›Paper›PMID 20464445›Full record

ArticleInvestigational new drugs2011

Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin.

Ki-Eun Hwang, Kyoung-Suk Na, Do-Sim Park, Keum-Ha Choi, Byoung-Ryun Kim, Hyeok Shim, Eun-Taik Jeong, Hak-Ryul Kim

Abstract read
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In one paragraph

Article in Investigational new drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  17. JNK signaling as a target for anticancer therapy.Pharmacological reports : PR · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ki-Eun HwangDepartment of Internal Medicine, Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, South Korea.
Kyoung-Suk Na
Do-Sim Park
Keum-Ha Choi
Byoung-Ryun Kim
Hyeok Shim
Eun-Taik Jeong
Hak-Ryul Kim
Wonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins, HMG-CoA reductase inhibitors have been studied for their antiproliferative and proapototic effects. Recently, statin-induced apoptosis has been associated with down-regulation of survivin expression in cancer cells. However, the mechanism of deregulated survivin by simvastatin on lung cancer is still unclear. Herein, we demonstrated that simvastatin induced caspase-dependent apoptosis in A549 lung cancer cells. Simvastatin also resulted in a decrease in the expression of phosphorylated Akt. In addition, simvastatin effectively down-regulated survivin mRNA and protein, but not cIAP-1 and cIAP-2. The combination of simvastatin and 10 μM LY294002 (non-toxic dose) augmented apoptosis significantly, as evidenced by cleavage of PARP. The immunoreactive band of survivin was markedly decreased in cells treated with 50 μM LY294002 (toxic dose) as well as by the combination of simvastatin and 10 μM LY294002. Moreover, survivin down-regulation by RNA interference induced apoptosis accompanied by an increase in hypodiploid DNA content. Taken together, these data suggest that the anti-cancer effect of simvastatin via induction of apoptosis is related to Akt signaling dependent down-regulation of survivin in lung cancer A549 cells.

Indexed as

ApoptosisCaspasesCell Line, TumorCell ProliferationCell SurvivalChromonesDown-RegulationDrug Screening Assays, AntitumorGene Expression Regulation, NeoplasticHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInhibitor of Apoptosis ProteinsLung NeoplasmsMorpholinesProto-Oncogene Proteins c-aktRNA, Small Interfering2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneBIRC5 protein, humanCaspasesChromonesHydroxymethylglutaryl-CoA Reductase InhibitorsInhibitor of Apoptosis ProteinsMorpholinesProto-Oncogene Proteins c-aktRNA, Small InterferingSimvastatinSurvivin

Identifiers

PMID20464445
OpenAlexW2074143992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.