ArticlePediatric nephrology (Berlin, Germany)2010
Risk for anemia in pediatric chronic kidney disease patients: a report of NAPRTCS.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Comparative efficacy of epoetin alfa vs. darbepoetin in children with chronic kidney disease: a systematic review, meta-analysis and cost-effectiveness analysis.Journal of nephrology · 2025Pooled it
- De novo weekly and biweekly darbepoetin alfa dosing in pediatric patients with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Trial
- Pilot study of the effect of cholecalciferol supplementation on hepcidin in children with chronic kidney disease: Results of the D-fense Trial.Pediatric nephrology (Berlin, Germany) · 2017Trial
- The Growth Attainment, Hematological, Iron Status and Inflammatory Profile of Guatemalan Juvenile End-Stage Renal Disease Patients.PloS one · 2015Trial
- Baseline height Z-score as an early marker of chronic kidney disease progression: insights from a two-year follow-up.Pediatric nephrology (Berlin, Germany) · 2026Article
- A cost-effective innovation in anaemia management for paediatric patients with haemodialysis-dependent chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Article
- Compassionate use of roxadustat for treatment of refractory renal anemia in an infant.Pediatric nephrology (Berlin, Germany) · 2024Article
- Fibroblast growth-factor 23 and vitamin D are associated with iron deficiency and anemia in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Association between serum biomarkers and oral health status in children with chronic kidney disease: A cross-sectional study.Clinical oral investigations · 2023Article
- Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity.Pediatric nephrology (Berlin, Germany) · 2023Article
- Anemia and Associated Risk Factors in Pediatric Patients.Pediatric health, medicine and therapeutics · 2023Review
- Use of erythropoiesis-stimulating agents in children with chronic kidney disease: a systematic review.Clinical kidney journal · 2022Review
- Chronic kidney disease causes and outcomes in children: Perspective from a LMIC setting.PloS one · 2022Article
- Epidemiology of Chronic Kidney Disease in Children: A Report from Lithuania.Medicina (Kaunas, Lithuania) · 2021Article
- Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis.International journal of nephrology · 2020Article
- Glomerular disease patients have higher odds not to reach quality targets in chronic dialysis compared with CAKUT patients: analyses from a nationwide German paediatric dialysis registry.Pediatric nephrology (Berlin, Germany) · 2019Article
- Measurement of iron status in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- HIF stabilizers in the management of renal anemia: from bench to bedside to pediatrics.Pediatric nephrology (Berlin, Germany) · 2019Review
- Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study.Journal of clinical medicine · 2019Article
- Anemia in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies in children with chronic kidney disease (CKD) have identified low hemoglobin as a risk factor for poor outcomes. A retrospective review of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) CKD registry was performed to identify the prevalence of and risk factors for anemia among children with stage 3 CKD, including both patients with low hemoglobin and those whose hemoglobin normalized with an erythropoiesis-stimulating agent (ESA). At enrollment, 2,792 patients had stage 3 CKD. Mean age was 9.5 (+/-0.11) years, 62.1% were male, 61.3% were white, and 43.7% had structural/urologic disease. Among 1,640 of those patients with 12 month follow-up data available for multivariate analysis, 73% met the criteria for anemia. Multivariate logistic regression analysis identifying risk factors for anemia at the 12-month follow-up revealed that, after controlling for estimated glomerular filtration rate, age >2 years, male sex, earlier era of study entry, and prescription of anti-hypertensive medications are associated with an increased risk for anemia at 12 months. In addition, multivariate Cox proportional hazards regression analysis revealed that when patients with ESA-corrected hemoglobin are included in the definition, anemia is not associated with increased risk of progression to end stage renal disease (dialysis initiation or transplantation).
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Registered trials
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