ArticleActa neuropathologica2010
Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.
Article in Acta neuropathologica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Establishing an RNA fusions panel in soft tissue sarcoma with clinical validation.Scientific reports · 2023Article
- A Meaningful Strategy for Glioma Diagnosis via Independent Determination of hsa_circ_0004214.Brain sciences · 2023Article
- Article
- Oligodendroglioma with ganglioglioma-like maturation: the histopathological diagnostic challenge of a brain neoplasm with aberrant neuronal component - A case report and review of the literature.Surgical neurology international · 2022Article
- Intracytoplasmic dot-like inclusions as cytopathologically useful findings of ependymoma: Case report of adolescent supratentorial anaplastic ependymoma with clear cell morphology.Clinical case reports · 2021Article
- Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs.Journal of comparative pathology · 2019Article
- H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components.Acta neuropathologica communications · 2019Article
- Pathologic and molecular aspects of anaplasia in circumscribed gliomas and glioneuronal tumors.Brain tumor pathology · 2019Review
- Extraventricular neurocytoma with ganglioid differentiation of the sellar and parasellar regions in an elderly patient: A case report.Surgical neurology international · 2019Article
- Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas.Brain pathology (Zurich, Switzerland) · 2017Article
- The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision.Neurologia medico-chirurgica · 2017Review
- Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.Acta neuropathologica · 2017Article
- Oligodendroglioma: pathology, molecular mechanisms and markers.Acta neuropathologica · 2015Review
- Pathology and genetics of diffuse gliomas in adults.Neurologia medico-chirurgica · 2015Review
- Long-term epilepsy-associated tumors.Brain pathology (Zurich, Switzerland) · 2012Review
- Ewing sarcoma/primitive neuroectodermal tumor of the kidney: two unusual presentations of a rare tumor.Case reports in medicine · 2012Article
- Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas.Brain pathology (Zurich, Switzerland) · 2011Article
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Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although oligodendroglial neoplasms are traditionally considered purely glial, increasing evidence suggests that they are capable of neuronal or neurocytic differentiation. Nevertheless, ganglioglioma-like foci (GGLF) have not been previously described. Herein, we report seven examples where the primary differential diagnosis was a ganglioglioma with an oligodendroglial component. These five male and two female patients ranged in age from 29 to 63 (median 44) years at initial presentation and neuroimaging features were those of diffuse gliomas in general. At presentation, the glial component was oligodendroglioma in six and oligoastrocytoma in one; one was low-grade and six were anaplastic. A sharp demarcation from adjacent GGLF was common, although some intermingling was always present. The GGLF included enlarged dysmorphic and occasionally binucleate ganglion cells, Nissl substance, expression of neuronal antigens, GFAP-positive astrocytic elements, and low Ki-67 labeling indices. In contrast to classic ganglioglioma, however, cases lacked eosinophilic granular bodies and CD34-positive tumor cells. Scattered bizarre astrocytes were also common and one case had focal neurocytic differentiation. By FISH analysis, five cases showed 1p/19q codeletion. In the four cases with deletions and ample dysmorphic ganglion cells for analysis, the deletions were found in both components. At last follow-up, two patients suffered recurrences, one developed radiation necrosis mimicking recurrence, and one died of disease 7.5 years after initial surgery. We conclude that GGLF represents yet another form of neuronal differentiation in oligodendroglial neoplasms. Recognition of this pattern will prevent a misdiagnosis of ganglioglioma with its potential for under-treatment.
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