ArticlePloS one2010
On the control of acute rodent malaria infections by innate immunity.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Understanding the traits underlying vaccine-driven virulence evolution in malaria parasites.BMC biology · 2025Article
- Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris.Nature microbiology · 2024Article
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- Differential drivers of intraspecific and interspecific competition during malaria-helminth co-infection.Parasitology · 2021Article
- Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes.PLoS computational biology · 2020Article
- Simulation modelling for immunologists.Nature reviews. Immunology · 2020Review
- What Controls the Acute Viral Infection Following Yellow Fever Vaccination?Bulletin of mathematical biology · 2018Article
- Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.Proceedings. Biological sciences · 2017Article
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Exploring the collaboration between antibiotics and the immune response in the treatment of acute, self-limiting infections.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Malarial pathocoenosis: beneficial and deleterious interactions between malaria and other human diseases.Frontiers in physiology · 2014Review
- Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites.PLoS computational biology · 2014Article
- Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.Journal of the Royal Society, Interface · 2012Article
- On the role of CD8 T cells in the control of persistent infections.Biophysical journal · 2012Article
- Article
- Causes of variation in malaria infection dynamics: insights from theory and data.The American naturalist · 2011Article
- Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.Science (New York, N.Y.) · 2011Article
- The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Does specific immunity, innate immunity or resource (red blood cell) limitation control the first peak of the blood-stage parasite in acute rodent malaria infections? Since mice deficient in specific immunity exhibit similar initial dynamics as wild-type mice it is generally viewed that the initial control of parasite is due to either limitation of resources (RBC) or innate immune responses. There are conflicting views on the roles of these two mechanisms as there is experimental evidence supporting both these hypotheses. While mathematical models based on RBC limitation are capable of describing the dynamics of primary infections, it was not clear whether a model incorporating the key features of innate immunity would be able to do the same. We examine the conditions under which a model incorporating parasite and innate immunity can describe data from acute Plasmodium chabaudi infections in mice. We find that innate immune response must decay slowly if the parasite density is to fall rather than equilibrate. Further, we show that within this framework the differences in the dynamics of two parasite strains are best ascribed to differences in susceptibility to innate immunity, rather than differences in the strains' growth rates or their propensity to elicit innate immunity. We suggest that further work is required to determine if innate immunity or resource limitation control acute malaria infections in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.