ArticleJournal of acquired immune deficiency syndromes (1999)2010
C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults.The Journal of infectious diseases · 2016Trial
- Decreased monocyte activation with daily acyclovir use in HIV-1/HSV-2 coinfected women.Sexually transmitted infections · 2015Trial
- Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma.PloS one · 2012Trial
- Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study ofViruses · 2024Article
- Long-term Trajectories of C-Reactive Protein Among Men Living With and Without HIV Infection in the Multicenter AIDS Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Evaluation of the diagnostic performance of laboratory-based c-reactive protein as a triage test for active pulmonary tuberculosis.PloS one · 2021Article
- Reply to "Is Ventricular Arrhythmias the End for All Conditions?"Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Article
- Point-of-care C-reactive protein and risk of early mortality among adults initiating antiretroviral therapy.AIDS (London, England) · 2019Article
- Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.The Journal of infectious diseases · 2019Article
- Altered Expression of CD300a Inhibitory Receptor on CD4+ T Cells From Human Immunodeficiency Virus-1-Infected Patients: Association With Disease Progression Markers.Frontiers in immunology · 2018Article
- Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Brief Report: Differential Associations of Interleukin 6 and Intestinal Fatty Acid-Binding Protein With Progressive Untreated HIV-1 Infection in Rakai, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Pre-cART Elevation of CRP and CD4+ T-Cell Immune Activation Associated With HIV Clinical Progression in a Multinational Case-Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- The secretion of IL-22 from mucosal NKp44⁺ NK cells is associated with microbial translocation and virus infection in SIV/SHIV-infected Chinese macaques.Journal of immunology research · 2014Article
- Gut Microbiota in HIV Infection: Implication for Disease Progression and Management.Gastroenterology research and practice · 2014Review
- HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function.Current HIV research · 2014Article
- Attenuation of immune activation in an open-label clinical trial for HIV-AIDS using a polyherbal formulation.Virusdisease · 2014Article
- Short communication: Evidence that microbial translocation occurs in HIV-infected children in the United Kingdom.AIDS research and human retroviruses · 2013Article
- Mucosal immunity in human and simian immunodeficiency lentivirus infections.Mucosal immunology · 2013Review
- Liver stiffness is associated with monocyte activation in HIV-infected Ugandans without viral hepatitis.AIDS research and human retroviruses · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionMicrobial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda, microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined.
methodsLongitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation.
resultsCRP levels significantly increased in the SP group (P < 0.0001) but not in the RP group or the LTNP group. CRP levels during the first year post-HIV seroconversion in the RP group were significantly higher than those observed in the LTNP group (P < 0.05). For the entire population, CRP levels negatively correlated with lipopolysaccharide levels (P < 0.05) and were not associated with endotoxin antibody levels.
conclusionsThis study suggests that in this population, increased immune activation is significantly associated with HIV-1 disease progression but not microbial translocation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.