ReviewBiology of reproduction2010
Rethinking the relationship between hyperactivation and chemotaxis in mammalian sperm.
Review in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 95 citations in OpenAlex.
- Effect of melatonin supplementation on sperm quality in dromedary camel (Camelus dromedarius) under physiological and short-term cold storage conditions.Tropical animal health and production · 2026Article
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm.Life science alliance · 2024Article
- Pyruvate modulation of redox potential controls mouse sperm motility.Developmental cell · 2024Article
- Human sperm rotate with a conserved direction during free swimming in four dimensions.Journal of cell science · 2023Article
- β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.Cell reports. Medicine · 2022Article
- Hyperactivation is sufficient to release porcine sperm from immobilized oviduct glycans.Scientific reports · 2022Article
- N-Formyl-L-aspartate mediates chemotaxis in spermFrontiers in cell and developmental biology · 2022Article
- Mammalian sperm hyperactivation regulates navigation via physical boundaries and promotes pseudo-chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rolling controls sperm navigation in response to the dynamic rheological properties of the environment.eLife · 2021Article
- Review
- Status of Sperm Functionality Assessment in Wildlife Species: From Fish to Primates.Animals : an open access journal from MDPI · 2021Review
- Differences and Similarities: The Richness of Comparative Sperm Physiology.Physiology (Bethesda, Md.) · 2020Review
- Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle.PloS one · 2020Article
- Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.Journal of clinical medicine · 2019Review
- Intracellular Ca2+ threshold reversibly switches flagellar beat off and on.Biology of reproduction · 2018Article
- 3D imaging of sex-sorted bovine spermatozoon locomotion, head spin and flagellum beating.Scientific reports · 2018Article
- The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.Biology of reproduction · 2018Article
- Computational imaging of sperm locomotion.Biology of reproduction · 2017Article
- Gamete activation: basic knowledge and clinical applications.Human reproduction update · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hyperactivation, a motility pattern of mammalian sperm in the oviduct, is essential to fertilization. Hyperactivation helps sperm to swim effectively through oviductal mucus, to escape from the sperm reservoir, and to penetrate the cumulus matrix and zona pellucida of the oocyte. There is some evidence that mammalian sperm can undergo chemotaxis; however, the relationship of chemotaxis to hyperactivation is unknown. Ca(2+) signaling is involved in hyperactivation and implicated in chemotaxis as well. In vivo, sperm hyperactivate in the lower oviduct, far from the cumulus-oocyte complex and possibly beyond the influence of chemotactic gradients emanating from the oocyte or cumulus. Thus, sperm are likely to be hyperactivated before sensing chemotactic gradients. Chemotactic signals might modulate hyperactivation to direct sperm toward oocytes as they reach a region of influence. Ca(2+)-directed modulation of hyperactivation is a potential mechanism of this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.