ArticleInvestigative ophthalmology & visual science2010
New-onset maternal gestational hypertension and risk of retinopathy of prematurity.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018Pooled it
- Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Association of Gestational Hypertensive Disorders with Retinopathy of prematurity: A Systematic Review and Meta-analysis.Scientific reports · 2016Pooled it
- Erythropoietin and retinopathy of prematurity: a meta-analysis.European journal of pediatrics · 2014Pooled it
- Association of hypertensive disorders of pregnancy and gestational diabetes mellitus with developing severe retinopathy of prematurity.International journal of retina and vitreous · 2025Article
- Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023Review
- Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023Review
- The association of various obstetric and perinatal factors with retinopathy of prematurity.International ophthalmology · 2022Article
- Development and Validation of a Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity.JAMA network open · 2022Article
- Endothelial dysfunction in preterm infants: The hidden legacy of uteroplacental pathologies.Frontiers in pediatrics · 2022Review
- Systemic Factors Associated with a Thinner Choroid in Preterm Infants.Ophthalmology science · 2021Article
- Pre-eclampsia and the risk of retinopathy of prematurity in preterm infants with birth weight <1500 g and/or <31 weeks' gestation.BMJ open ophthalmology · 2017Article
- Incidence and risk factors of retinopathy of prematurity in two neonatal intensive care units in North and South China.Chinese medical journal · 2015Article
- Preeclampsia and retinopathy of prematurity in preterm births.Pediatrics · 2012Article
- Association between assisted reproductive technology and advanced retinopathy of prematurity.Clinical ophthalmology (Auckland, N.Z.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate associations between conditions of maternal new-onset gestational hypertension (mHTN) and the features imparting risk of severe retinopathy of prematurity (ROP) in preterm infants.
methodsHospital databases and charts of all preterm inborn infants at the University of North Carolina from 1996 to 2007 were retrospectively reviewed. The presence or absence of mHTN (e.g., pre-eclampsia) and infant factors (birthweight, gestational age, erythropoietin use, and zone and stage of ROP) were analyzed for independence of association.
resultsOf the 5143 infants, 323 had ROP and 76 had mothers with mHTN. Infants with ROP were more likely to have mothers with mHTN and to be younger and smaller at birth. At initial examination, more infants of mothers with mHTN had vascularization into the lower zones than did infants of mothers without mHTN (P < 0.001). However, at the examination in which the most severe ROP was present, there was no association between mHTN and ROP stage (P = 0.2342). Analysis of stage and zone together showed that infants born to mothers with mHTN were more likely to have ROP at initial examination, after adjustment for gestational age, but not for birth weight. The use of erythropoietin was not associated with ROP zone or stage, even after adjustment for maternal condition, infant birth weight, or gestational age.
conclusionsAlthough larger avascular areas or higher severity scores were associated with mHTN after adjustment for gestational age at initial examination, no associations were found between mHTN and ROP severity score at the examination when ROP was most severe. There were no associations between ROP severity and treatment with erythropoietin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.