ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Enteric glia are targets of the sympathetic innervation of the myenteric plexus in the guinea pig distal colon.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 99 citations in OpenAlex.
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- The role of reactive enteric glia-macrophage interactions in acute and chronic inflammation.Neurogastroenterology and motility · 2025Review
- The Physiology of Enteric Glia.Annual review of physiology · 2025Review
- β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.Journal of neuroinflammation · 2023Article
- Mini-review: Intercellular communication between enteric glia and neurons.Neuroscience letters · 2023Review
- Cytological, molecular, cytogenetic, and physiological characterization of a novel immortalized human enteric glial cell line.Frontiers in cellular neuroscience · 2023Article
- Circadian rhythms in colonic function.Frontiers in physiology · 2023Review
- Functional Intraregional and Interregional Heterogeneity between Myenteric Glial Cells of the Colon and Duodenum in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?Molecules (Basel, Switzerland) · 2022Review
- Bio-impedance method to monitor colon motility response to direct distal colon stimulation in anesthetized pigs.Scientific reports · 2022Article
- Insights on gastrointestinal motility through the use of optogenetic sensors and actuators.The Journal of physiology · 2022Review
- Enteric glial biology, intercellular signalling and roles in gastrointestinal disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses.Gastroenterology · 2021Article
- Regulation of the Autonomic Nervous System on Intestine.Frontiers in physiology · 2021Review
- Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease.International journal of molecular sciences · 2020Review
- Functional circuits and signal processing in the enteric nervous system.Cellular and molecular life sciences : CMLS · 2020Review
- NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Article
- Enteric Glia: A New Player in Abdominal Pain.Cellular and molecular gastroenterology and hepatology · 2019Review
- Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?Cellular and molecular life sciences : CMLS · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Astrocytes respond to synaptic activity in the CNS. Astrocytic responses are synapse specific and precisely regulate synaptic activity. Glia in the peripheral nervous system also respond to neuronal activity, but it is unknown whether glial responses are synapse specific. We addressed this issue by examining the activation of enteric glia by distinct neuronal subpopulations in the enteric nervous system. Enteric glia are unique peripheral glia that surround enteric neurons and respond to neuronally released ATP with increases in intracellular calcium ([Ca2+]i). Autonomic control of colonic function is mediated by intrinsic (enteric) and extrinsic (sympathetic, parasympathetic, primary afferent) neural pathways. Here we test the hypothesis that a defined population of neurons activates enteric glia using a variety of techniques to ablate or stimulate components of the autonomic innervation of the colon. Our findings demonstrate that, in the male guinea pig colon, activation of intrinsic neurons does not stimulate glial [Ca2+]i responses and fast enteric neurotransmission is not necessary to initiate glial responses. However, ablating extrinsic innervation significantly reduces glial responses to neuronal activation. Activation of primary afferent fibers does not activate glial [Ca2+]i responses. Selectively ablating sympathetic fibers reduces glial activation to a similar extent as total extrinsic denervation. Neuronal activation of glia follows the same frequency dependence as sympathetic neurotransmitter release, but the only sympathetic neurotransmitter that activates glial [Ca2+]i responses is ATP, suggesting that sympathetic fibers release ATP to activate enteric glia. Therefore, enteric glia discern activity in adjacent synaptic pathways and selectively respond to sympathetic activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.