ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Evidence for the involvement of Lfc and Tctex-1 in axon formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Dual spatio-temporal regulation of axon growth and microtubule dynamics by RhoA signaling pathways.Journal of cell science · 2024Article
- Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex.Molecular psychiatry · 2023Article
- Changes in and asymmetry of the proteome in the human fetal frontal lobe during early development.Communications biology · 2022Article
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- Perspectives on Mechanisms Supporting Neuronal Polarity From Small Animals to Humans.Frontiers in cell and developmental biology · 2022Review
- The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.Molecular biology of the cell · 2021Article
- ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.Translational psychiatry · 2020Article
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- Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach.Neural regeneration research · 2019Review
- Neuronal Polarity: Positive and Negative Feedback Signals.Frontiers in cell and developmental biology · 2019Article
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.International journal of molecular sciences · 2018Review
- Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis.The Journal of cell biology · 2017Article
- Discovery of long-range inhibitory signaling to ensure single axon formation.Nature communications · 2017Article
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- Upregulation of the GEF-H1 pathway after transient cerebral ischemia.Experimental neurology · 2015Article
- Rho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamics.Small GTPases · 2014Review
- Changes in the GEF-H1 pathways after traumatic brain injury.Journal of neurotrauma · 2013Article
- Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons.PloS one · 2013Article
- Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.