ArticleJournal of neurophysiology2010
Gamma band unit activity and population responses in the pedunculopontine nucleus.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 82 citations in OpenAlex.
- Modulating the cholinergic system-Novel targets for deep brain stimulation in Parkinson's disease.Journal of neurochemistry · 2025Review
- Low frequency ultrasound elicits broad cortical responses inhibited by ketamine in mice.Communications engineering · 2024Article
- Evolutionary origin of alpha rhythms in vertebrates.Frontiers in behavioral neuroscience · 2024Review
- Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics · 2023Article
- The Mesencephalic Locomotor Region: Beyond Locomotor Control.Frontiers in neural circuits · 2022Review
- Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo.Neuropharmacology · 2020Article
- Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus.Journal of neuroscience research · 2019Review
- Concerns regarding Baksa B, Kovacs A, Bayasgalan T, Szentesi P, Koseghy A, Szucs P, Balazs P. Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus. Cell Molec. Life Sci. 2019-04-02.Cellular and molecular life sciences : CMLS · 2019Article
- Response to "Concerns regarding Baksa et al., Cell Molec. Life Sci., 2019." by Edgar Garcia-Rill and Francisco J. Urbano (CMLS-D-18-0156R1).Cellular and molecular life sciences : CMLS · 2019Article
- Bottom-up gamma maintenance in various disorders.Neurobiology of disease · 2019Review
- Proteomic measures of gamma oscillations.Heliyon · 2019Article
- Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus.Cellular and molecular life sciences : CMLS · 2019Article
- Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Bottom-up gamma and bipolar disorder, clinical and neuroepigenetic implications.Bipolar disorders · 2019Review
- Pedunculopontine Nucleus Degeneration Contributes to Both Motor and Non-Motor Symptoms of Parkinson's Disease.Frontiers in pharmacology · 2019Review
- The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics.AIMS neuroscience · 2019Review
- Class II histone deacetylases require P/Q-type CaScientific reports · 2018Article
- Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy.Drug design, development and therapy · 2018Review
- Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.Frontiers in neurology · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The pedunculopontine nucleus (PPN) is involved in the activated states of waking and paradoxical sleep, forming part of the reticular activating system (RAS). The studies described tested the hypothesis that single unit and/or population responses of PPN neurons are capable of generating gamma band frequency activity. Whole cell patch clamp recordings (immersion chamber) and population responses (interface chamber) were conducted on 9- to 20-day-old rat brain stem slices. Regardless of cell type (I, II, or III) or type of response to the nonselective cholinergic receptor agonist carbachol (excitation, inhibition, biphasic), almost all PPN neurons fired at gamma band frequency, but no higher, when subjected to depolarizing steps (50 +/- 2 Hz, mean +/- SE). Nonaccommodating neurons fired at 18-100 Hz throughout depolarizing steps, while most accommodating neurons exhibited gamma band frequency of action potentials followed by gamma band membrane oscillations. These oscillations were blocked by the sodium channel blocker tetrodotoxin (TTX), suggesting that at least some are mediated by sodium currents. Population responses in the PPN showed that carbachol induced peaks of activation in the theta and gamma range, while glutamatergic receptor agonists induced overall increases in activity at theta and gamma frequencies, although in differing patterns. Gamma band activity appears to be a part of the intrinsic membrane properties of PPN neurons, and the population as a whole generates different patterns of gamma band activity under the influence of specific transmitters. Given sufficient excitation, the PPN may impart gamma band activation on its targets.
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