Evidence map›Paper›PMID 20463189›Full record

ReviewRheumatology (Oxford, England)2010

Treating arthritis by immunomodulation: is there a role for regulatory T cells?

Ellen J Wehrens, Femke van Wijk, Sarah T Roord, Salvatore Albani, Berent J Prakken

Abstract readReview
In one paragraph

Review in Rheumatology (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ellen J WehrensDepartment of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht (UMCU), Lundlaan 6, 3584 EA, Utrecht, The Netherlands. e.j.m.wehrens@umcutrecht.nl
Femke van Wijk
Sarah T Roord
Salvatore Albani
Berent J Prakken

Funding

Immune tolerance in the therapy of rheumatoid arthritisR01AI084551 · NIAID · UNIVERSITY OF ARIZONA · PI ALBANI, SALVATORE · 2009 to 2010
$755k
NIAID NIH HHS R01 AI084551
6 · The paper itself

Abstract

The discovery of regulatory T cells almost 15 years ago initiated a new and exciting research area. The growing evidence for a critical role of these cells in controlling autoimmune responses has raised expectations for therapeutic application of regulatory T cells in patients with autoimmune arthritis. Here, we review recent studies investigating the presence, phenotype and function of these cells in patients with RA and juvenile idiopathic arthritis (JIA) and consider their therapeutic potential. Both direct and indirect methods to target these cells will be discussed. Arguably, a therapeutic approach that combines multiple regulatory T-cell-enhancing strategies could be most successful for clinical application.

Indexed as

ArthritisArthritis, RheumatoidAutoimmunityHumansImmunomodulationT-Lymphocytes, Regulatory

Identifiers

PMID20463189
PMCPMC3203406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.