ArticleJournal of clinical microbiology2010
Correlation of parasite load determined by quantitative PCR to clinical outcome in a heart transplant patient with disseminated toxoplasmosis.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- Beyond Latency: ChronicBiomedicines · 2025Review
- Ocular Toxoplasmosis: Advances inPathogens (Basel, Switzerland) · 2024Review
- Recent and past toxoplasmosis infections, associated factors, and awareness among pregnant women in Nigeria.SAGE open medicine · 2023Article
- PCR-based diagnosis is not always useful in the acute acquired toxoplasmosis in immunocompetent individuals.Parasitology research · 2021Article
- Review
- Pneumonia in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.Clinical transplantation · 2019Review
- Toxoplasmosis in Transplant Recipients, Europe, 2010-2014.Emerging infectious diseases · 2018Article
- Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades.Pathogens (Basel, Switzerland) · 2018Review
- Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden.PLoS neglected tropical diseases · 2016Article
- Molecular diagnosis of toxoplasmosis in immunocompromised patients: a 3-year multicenter retrospective study.Journal of clinical microbiology · 2015Article
- Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases.Acta physiologica (Oxford, England) · 2015Review
- Atypical strain of Toxoplasma gondii causing fatal reactivation after hematopoietic stem cell transplantion in a patient with an underlying immunological deficiency.Journal of clinical microbiology · 2013Article
- Varicella-like cutaneous toxoplasmosis in a patient with aplastic anemia.Journal of clinical microbiology · 2013Article
- Epidemiology of and diagnostic strategies for toxoplasmosis.Clinical microbiology reviews · 2012Review
- Diagnosis of ocular toxoplasmosis by two polymerase chain reaction (PCR) examinations: qualitative multiplex and quantitative real-time.Japanese journal of ophthalmology · 2011Article
- Alternative Pneumocystis Pneumonia Prophylaxis in Solid Organ Transplants.Transplant infectious disease : an official journal of the Transplantation SocietyArticle
- Detection ofIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disseminated toxoplasmosis is a life-threatening infection in transplant recipients, which results either from reactivation of latent infection or from organ-transmitted primary infection. Preventive measures and diagnostic screening methods differ between countries and are related to the seroprevalence of Toxoplasma spp. in the general population. Here we report a case of disseminated toxoplasmosis in a heart transplant recipient with previous immunity that occurred after cotrimoxazole prophylaxis for the prevention of Pneumocystis jirovecii pneumonia was stopped. Quantitative PCR proved useful for the diagnosis and monitoring of Toxoplasma infection. Decreasing parasitic burdens in sequential samples of cerebrospinal fluid, blood, and bronchoalveolar lavage fluid correlated with a favorable outcome and allowed modulation of the immunosuppressive drug regimen. The duration of anti-Toxoplasma treatment and the need for maintenance prophylaxis are discussed, as well as prophylaxis for solid-organ transplant recipients. Although a rare event in heart transplant recipients, Toxoplasma reactivation must be investigated promptly, since early treatment improves the prognosis.
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