ArticleJournal of clinical microbiology2010
Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Granuloma and persistent detection of wild-type rubella virus in an immunocompromised patient.Microbiology spectrum · 2025Article
- Pluripotent Stem Cell-Based Models: A Peephole into Virus Infections during Early Pregnancy.Cells · 2020Review
- Phylogeography of rubella virus in Asia: Vaccination and demography shape synchronous outbreaks.Epidemics · 2019Article
- Analysis of complete genomes of the rubella virus genotypes 1E and 2B which circulated in China, 2000-2013.Scientific reports · 2016Article
- Article
- Application of Oral Fluid Assays in Support of Mumps, Rubella and Varicella Control Programs.Vaccines · 2015Review
- Molecular evolutionary and epidemiological dynamics of genotypes 1G and 2B of rubella virus.PloS one · 2014Article
- Molecular epidemiology of rubella viruses involved in congenital rubella infections in São Paulo, Brazil, between 1996 and 2009.Journal of medical virology · 2013Article
- Rubella epidemic caused by genotype 1E rubella viruses in Beijing, China, in 2007-2011.Virology journal · 2013Article
- Viral invasion of the amniotic cavity (VIAC) in the midtrimester of pregnancy.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2012Article
- Emergence and continuous evolution of genotype 1E rubella viruses in China.Journal of clinical microbiology · 2012Article
- Rubella epidemics and genotypic distribution of the rubella virus in Shandong Province, China, in 1999-2010.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rubella is an acute infectious disease that normally has a mild clinical course. However, infections during pregnancy, especially before week 12 of gestation (WG), can cause severe birth defects known as congenital rubella syndrome (CRS). The aim of this study was to perform genotyping and molecular characterization of rubella viruses involved in congenital infections in France over the past 15 years (1995 to 2009). Amniotic fluid (AF) specimens (n = 80) from pregnant women with congenital rubella infections (CRI) before week 20 of gestation, and a few other samples available from children/newborns with CRS (n = 26), were analyzed. The coding region of the rubella virus E1 gene was amplified directly from clinical specimens by reverse transcriptase PCR, and the resulting DNA fragments were sequenced. Sequences were assigned to genotypes by phylogenetic analysis with rubella virus reference sequences. Sufficient E1 gene sequences were obtained from 56 cases. Phylogenetic analysis of the sequences showed that at least five different genotypes (1E, 1G, 1B, 2B, and 1h) were present in France and were involved in congenital infections, with a strong predominance of genotype 1E (87%). This is one of the very few comprehensive studies of rubella viruses involved in CRI. The results indicated that over the past 15 years, multiple introductions of the dominant genotype E caused most of the CRI cases in France. A few sporadic cases were due to other genotypes (1B, 1G, 1h, 2B).
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