Evidence map›Paper›PMID 20462379›Full record

ReviewAnnual review of biophysics2010

Chromatin dynamics.

Michael R Hübner, David L Spector

Abstract readReview
In one paragraph

Review in Annual review of biophysics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 176 citations in OpenAlex.

  1. Active processes shape and move the genome and nucleoplasm.Current opinion in genetics & development · 2026
    Review
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  14. Structure-function analyses revealCurrent research in structural biology · 2024
    Article
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael R HübnerCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. huebner@cshl.edu
David L Spector
Cold Spring Harbor Laboratory · US

Funding

VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
Nanomedicine Center for Nucleoprotein MachinesPN2EY018244 · NEI · RICE UNIVERSITY · PI BAO, GANG · 2006 to 2015
$24.4M
Spatial Organization of Gene ExpressoinR01GM042694 · NIGMS · COLD SPRING HARBOR LABORATORY · PI SPECTOR, DAVID L · 1990 to 2018
$12.7M
NCI NIH HHS 5P01CA013106-38NCI NIH HHS P01 CA013106NEI NIH HHS EY 18244NEI NIH HHS PN2 EY018244NIGMS NIH HHS GM 42694NIGMS NIH HHS R01 GM042694
6 · The paper itself

Abstract

The expression patterns of many protein-coding genes are orchestrated in response to exogenous stimuli, as well as cell-type-specific developmental programs. In recent years, researchers have shown that dynamic chromatin movements and interactions in the nucleus play a crucial role in gene regulation. In this review, we highlight our current understanding of the organization of chromatin in the interphase nucleus and the impact of chromatin dynamics on gene expression. We also discuss the current state of knowledge with regard to the localization of active and inactive genes within the three-dimensional nuclear space. Furthermore, we address recent findings that demonstrate the movements of chromosomal regions and genomic loci in association with changes in transcriptional activity. Finally, we discuss the role of intra- and interchromosomal interactions in the control of coregulated genes.

Indexed as

Gene Expression RegulationAnimalsCell NucleusChromatinHumansInterphaseChromatin

Identifiers

PMID20462379
PMCPMC2894465
OpenAlexW4242410054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.