ArticleThe journal of physical chemistry. B2010
Two-photon microscopy of oxygen: polymersomes as probe carrier vehicles.
Article in The journal of physical chemistry. B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy.STAR protocols · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.ACS applied materials & interfaces · 2019Article
- Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors.Journal for immunotherapy of cancer · 2019Article
- Oxyphor 2P: A High-Performance Probe for Deep-Tissue Longitudinal Oxygen Imaging.Cell metabolism · 2019Article
- Small Vessels Are a Big Problem in Neurodegeneration and Neuroprotection.Frontiers in neurology · 2019Review
- In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain.Nature protocols · 2018Article
- Two-photon antenna-core oxygen probe with enhanced performance.Analytical chemistry · 2014Article
- Article
- Two-photon oxygen sensing with quantum dot-porphyrin conjugates.Inorganic chemistry · 2013Article
- Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging.Analytical chemistry · 2011Article
- Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels.Nature medicine · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Oxygen concentration distributions in biological systems can be imaged by the phosphorescence quenching method in combination with two-photon laser scanning microscopy. In this paper, we identified the excitation regime in which the signal of a two-photon-enhanced phosphorescent probe (Finikova, O. S.; Lebedev, A. Y.; Aprelev, A.; Troxler, T.; Gao, F.; Garnacho, C.; Muro, S.; Hochstrasser, R. M.; Vinogradov, S. A. ChemPhysChem 2008, 9, 1673-1679) is dependent quadratically on the excitation power (quadratic regime), and performed simulations that relate the photophysical properties of the probe to the imaging resolution. Further, we characterized polymersomes as a method of probe encapsulation and delivery. Photophysical and oxygen sensing properties of the probe were found unchanged when the probe is encapsulated in polymersomes. Polymersomes were found capable of sustaining high probe concentrations, thereby serving to improve the signal-to-noise ratios for oxygen detection compared to the previously employed probe delivery methods. Imaging of polymersomes loaded with the probe was used as a test-bed for a new method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.