Trial reportDiabetologia2010
A family history of type 2 diabetes increases risk factors associated with overfeeding.
Trial report in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Excess Energy Intake on Metabolic Risk
Insulin-sensitive Obesity: Prospective and Interventional Studies
Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Proteomic Analysis of Human Plasma during Intermittent Fasting.Journal of proteome research · 2019Trial
- Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans.PloS one · 2013Trial
- Sleep Duration Alters Overfeeding-mediated Reduction in Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2025Article
- Associations Between Birth Characteristics, Weaning Practices, and the Metabolic Syndrome in Children: A Descriptive Study.Metabolites · 2025Article
- The role of high fat diet on serum uric acid level among healthy male first degree relatives of type 2 diabetes mellitus.Scientific reports · 2023Article
- Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes.Healthcare (Basel, Switzerland) · 2021Article
- The effect of body acid-base state and manipulations on body glucose regulation in human.European journal of clinical nutrition · 2020Review
- Metabolism and epigenetics of pancreatic cancer stem cells.Seminars in cancer biology · 2019Review
- Longitudinal Changes in Insulin Resistance in Normal Weight, Overweight and Obese Individuals.Journal of clinical medicine · 2019Article
- Friendly Fat Theory - Explaining the Paradox of Diabetes and Obesity.European endocrinology · 2019Review
- Article
- What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications?International journal of obesity (2005) · 2017Review
- Metabolically healthy versus unhealthy obesity and risk for diabetes mellitus and cardiovascular diseases.Cardiovascular endocrinology · 2017Review
- Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.Nutrition & diabetes · 2016Article
- Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity.NPJ systems biology and applications · 2015Article
- Article
- Clinical effects of high-fat meals and weight gain due to high-fat feeding.International journal of obesity supplements · 2012Review
- Selective breeding of mice for different susceptibilities to high fat diet-induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet-induced Glucose intolerance-Prone and -Resistant.Journal of diabetes investigation · 2012Article
- Article
- Insulin sensitivity and regional fat gain in response to overfeeding.Obesity (Silver Spring, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe purpose of the study was to test prospectively whether healthy individuals with a family history of type 2 diabetes are more susceptible to adverse metabolic effects during experimental overfeeding.
methodsWe studied the effects of 3 and 28 days of overfeeding by 5,200 kJ/day in 41 sedentary individuals with and without a family history of type 2 diabetes (FH+ and FH- respectively). Measures included body weight, fat distribution (computed tomography) and insulin sensitivity (hyperinsulinaemic-euglycaemic clamp).
resultsBody weight was increased compared with baseline at 3 and 28 days in both groups (p < 0.001), FH+ individuals having gained significantly more weight than FH- individuals at 28 days (3.4 +/- 1.6 vs 2.2 +/- 1.4 kg, p < 0.05). Fasting serum insulin and C-peptide were increased at 3 and 28 days compared with baseline in both groups, with greater increases in FH+ than in FH- for insulin at +3 and +28 days (p < 0.01) and C-peptide at +28 days (p < 0.05). Fasting glucose also increased at both time points, but without a significant group effect (p = 0.1). Peripheral insulin sensitivity decreased in the whole cohort at +28 days (54.8 +/- 17.7 to 50.3 +/- 15.6 micromol min(-1) [kg fat-free mass](-1), p = 0.03), and insulin sensitivity by HOMA-IR decreased at both time points (p < 0.001) and to a greater extent in FH+ than in FH- (p = 0.008). Liver fat, subcutaneous and visceral fat increased similarly in the two groups (p < 0.001).
conclusionsOverfeeding induced weight and fat gain, insulin resistance and hepatic fat deposition in healthy individuals. However, individuals with a family history of type 2 diabetes gained more weight and greater insulin resistance by HOMA-IR. The results of this study suggest that healthy individuals with a family history of type 2 diabetes are predisposed to adverse effects of overfeeding.
trial registrationClinicalTrials.gov NCT00562393
fundingThe study was funded by the National Health and Medical Research Council (NHMRC), Australia (no. #427639).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.