ArticleFrontiers in neural circuits2010
Orchestration of "presto" and "largo" synchrony in up-down activity of cortical networks.
Article in Frontiers in neural circuits, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 30 citations in OpenAlex.
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- Neuron-glia cross talk revealed in reverberating networks by simultaneous extracellular recording of spikes and astrocytes' glutamate transporter and K+ currents.Journal of neurophysiology · 2016Article
- Synaptic scaling rule preserves excitatory-inhibitory balance and salient neuronal network dynamics.Nature neuroscience · 2016Article
- Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks.Scientific reports · 2016Article
- Shaping Neuronal Network Activity by Presynaptic Mechanisms.PLoS computational biology · 2015Article
- NeuroCa: integrated framework for systematic analysis of spatiotemporal neuronal activity patterns from large-scale optical recording data.Neurophotonics · 2015Article
- Slow dynamics in features of synchronized neural network responses.Frontiers in computational neuroscience · 2015Article
- Adaptation to prolonged neuromodulation in cortical cultures: an invariable return to network synchrony.BMC biology · 2014Article
- DOC2B and Munc13-1 differentially regulate neuronal network activity.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
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- Atypical "seizure-like" activity in cortical reverberating networks in vitro can be caused by LPS-induced inflammation: a multi-electrode array study from a hundred neurons.Frontiers in cellular neuroscience · 2014Article
- Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy.Frontiers in neural circuits · 2014Article
- Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study.Frontiers in neural circuits · 2012Article
- Exact distinction of excitatory and inhibitory neurons in neural networks: a study with GFP-GAD67 neurons optically and electrophysiologically recognized on multielectrode arrays.Frontiers in neural circuits · 2012Article
- Physiological characterization of human muscle acetylcholine receptors from ALS patients.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- EphA4 expression promotes network activity and spine maturation in cortical neuronal cultures.Neural development · 2011Article
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8 authors at 1 institution in 1 country.
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Abstract
It has been demonstrated using single-cell and multiunit electrophysiology in layer III entorhinal cortex and disinhibited hippocampal CA3 slices that the balancing of the up-down activity is characterized by both GABA(A) and GABA(B) mechanisms. Here we report novel results obtained using multi-electrode array (60 electrodes) simultaneous recordings from reverberating postnatal neocortical networks containing 19.2 +/- 1.4% GABAergic neurons, typical of intact tissue. We observed that in each spontaneous active-state the total number of spikes in identified clusters of excitatory and inhibitory neurons is almost equal, thus suggesting a balanced average activity. Interestingly, in the active-state, the early phase is sustained by only 10% of the total spikes and the firing rate follows a sigmoidal regenerative mode up to peak at 35 ms with the number of excitatory spikes greater than inhibitory, therefore indicating an early unbalance. Concentration-response pharmacology of up- and down-state lifetimes in clusters of excitatory (n = 1067) and inhibitory (n = 305) cells suggests that, besides the GABA(A) and GABA(B) mechanisms, others such as GAT-1-mediated uptake, I(h), I(NaP) and I(M) ion channel activity, robustly govern both up- and down-activity. Some drugs resulted to affect up- and/or down-states with different IC(50)s, providing evidence that various mechanisms are involved. These results should reinforce not only the role of synchrony in CNS networks, but also the recognized analogies between the Hodgkin-Huxley action potential and the population bursts as basic mechanisms for originating membrane excitability and CNS network synchronization, respectively.
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