ArticleKorean journal of radiology
Quantitative assessment of the T2 relaxation time of the gluteus muscles in children with Duchenne muscular dystrophy: a comparative study before and after steroid treatment.
Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Using MRI to quantify skeletal muscle pathology in Duchenne muscular dystrophy: A systematic mapping review.Muscle & nerve · 2021Pooled it
- Quantitative magnetic resonance imaging measures as biomarkers of disease progression in boys with Duchenne muscular dystrophy: a phase 2 trial of domagrozumab.Journal of neurology · 2022Trial
- Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.Neurology · 2014Trial
- The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review.Frontiers in immunology · 2025Article
- Draft Guidance for Industry Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and Related Dystrophinopathies - Developing Potential Treatments for the Entire Spectrum of Disease.Journal of neuromuscular diseases · 2024Article
- Volume and T2 relaxation time measurements of quadriceps femoris and hamstring muscles are reliable and reproducibleTurkish journal of medical sciences · 2021Article
- T2 Mapping and Fat Quantification of Thigh Muscles in Children with Duchenne Muscular Dystrophy.Current medical science · 2019Article
- Dynamic contrast-enhanced magnetic resonance imaging in denervated skeletal muscle: Experimental study in rabbits.PloS one · 2019Article
- Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives.Frontiers in neurology · 2019Review
- Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.Journal of neurology · 2017Article
- Longitudinal MRI quantification of muscle degeneration in Duchenne muscular dystrophy.Annals of clinical and translational neurology · 2016Article
- MRI biomarker assessment of neuromuscular disease progression: a prospective observational cohort study.The Lancet. Neurology · 2016Observational
- Imaging techniques for muscle injury in sports medicine and clinical relevance.Current reviews in musculoskeletal medicine · 2015Article
- Effectiveness of diffusion tensor imaging in assessing disease severity in Duchenne muscular dystrophy: preliminary study.Pediatric radiology · 2015Article
- Reply to Drs. Azzabou and Carlie regarding objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.Pediatric radiology · 2014Article
- Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle.Magnetic resonance in medicine · 2014Article
- Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.Neuromuscular disorders : NMD · 2014Article
- Muscle MRI in patients with long-chain fatty acid oxidation disorders.Journal of inherited metabolic disease · 2014Article
- Objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.Pediatric radiology · 2014Article
- Analysis of fatty infiltration and inflammation of the pelvic and thigh muscles in boys with Duchenne muscular dystrophy (DMD): grading of disease involvement on MR imaging and correlation with clinical assessments.Pediatric radiology · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the feasibility of using T2 mapping as a quantitative method to longitudinally follow the disease activity in children with Duchenne muscular dystrophy (DMD) who are treated with steroids. MATERIALS AND
methodsELEVEN BOYS WITH DMD (AGE RANGE: 5-14 years) underwent evaluation with the clinical functional score (CFS), and conventional pelvic MRI and T2 mapping before and during steroid therapy. The gluteus muscle inflammation and fatty infiltration were evaluated on conventional MRI. The histograms and mean T2 relaxation times were obtained from the T2 maps. The CFS, the conventional MRI findings and the T2 values were compared before and during steroid therapy.
resultsNone of the patients showed interval change of their CFSs. On conventional MRI, none of the images showed muscle inflammation. During steroid treatment, two boys showed increased fatty infiltration on conventional MRI, and both had an increase of the mean T2 relaxation time (p < 0.05). The remaining nine boys had no increase in fatty infiltration. Of these, three showed an increased mean T2 relaxation time (p < 0.05), two showed no change and four showed a decreased mean T2 relaxation time (p < 0.05).
conclusionT2 mapping is a feasible technique to evaluate the longitudinal muscle changes in those children who receive steroid therapy for DMD. The differences of the mean T2 relaxation time may reflect alterations in disease activity, and even when the conventional MRI and CFS remain stable.
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