ArticleFrontiers in molecular neuroscience2010
The specification of glycinergic neurons and the role of glycinergic transmission in development.
Article in Frontiers in molecular neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Association of type 1 stiff-person syndrome and insulinoma: a case report and narrative review.Hormones (Athens, Greece) · 2025Review
- Inhibitory Systems in Brain Evolution: Pathways of Vulnerability in Neurodevelopmental Disorders.Brain, behavior and evolution · 2025Review
- An update on malignant tumor-related stiff person syndrome spectrum disorders: clinical mechanism, treatment, and outcomes.Frontiers in neurology · 2023Review
- Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.International journal of molecular sciences · 2022Review
- Glycine neurotransmission: Its role in development.Frontiers in neuroscience · 2022Review
- The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo.Communications biology · 2021Article
- Advances in hyperekplexia and other startle syndromes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Excessive Startle with NovelJournal of clinical neurology (Seoul, Korea) · 2020Article
- The Downregulation ofFrontiers in cell and developmental biology · 2020Article
- Glycine Transporter 1 Encephalopathy From Biochemical Pathway to Clinical Disease: Review.Child neurology open · 2019Review
- Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans.Human genetics · 2016Article
- Impact of sex differences in brain response to infection with Plasmodium berghei.Parasitology research · 2016Article
- Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni.Parasitology research · 2015Article
- Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern.Nature neuroscience · 2015Article
- The impact of human hyperekplexia mutations on glycine receptor structure and function.Molecular brain · 2014Review
- Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?Frontiers in molecular neuroscience · 2012Article
- Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.Histochemistry and cell biology · 2011Article
- Glycinergic transmission: physiological, developmental and pathological implications.Frontiers in molecular neuroscience · 2010Article
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2 authors.
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Abstract
Glycine's role as an inhibitory neurotransmitter in the adult vertebrate nervous system has been well characterized in a number of different model organisms. However, a full understanding of glycinergic transmission requires a knowledge of how glycinergic synapses emerge and the role of glycinergic signaling during development. Recent literature has provided a detailed picture of the developmental expression of many of the molecular components that comprise the glycinergic phenotype, namely the glycine transporters and the glycine receptor subunits; the transcriptional networks leading to the expression of this important neurotransmitter phenotype are also being elucidated. An equally important focus of research has revealed the critical role of glycinergic signaling in sculpting many different aspects of neural development. This review examines the current literature detailing the expression patterns of the components of the glycinergic phenotype in various vertebrate model organisms over the course of development and the molecular mechanisms governing the expression of the glycinergic phenotype. The review then surveys the recent work on the role of glycinergic signaling in the developing nervous system and concludes with an overview of areas for further research.
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