ArticleCellular and molecular bioengineering2010
Model Convolution: A Computational Approach to Digital Image Interpretation.
Article in Cellular and molecular bioengineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- VEGFR2 dimerization kinetics on the cell surface determined by microscopy and mathematical modeling.Biophysical journal · 2026Article
- Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends.eLife · 2024Article
- Measurement of the persistence length of cytoskeletal filaments using curvature distributions.Biophysical journal · 2022Article
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- Shaping centromeres to resist mitotic spindle forces.Journal of cell science · 2022Article
- Tau Avoids the GTP Cap at Growing Microtubule Plus-Ends.iScience · 2020Article
- A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.Nature structural & molecular biology · 2017Article
- Physical limits on kinesin-5-mediated chromosome congression in the smallest mitotic spindles.Molecular biology of the cell · 2015Article
- A Model-based approach for microvasculature structure distortion correction in two-photon fluorescence microscopy images.Journal of microscopy · 2015Article
- Pericentromere tension is self-regulated by spindle structure in metaphase.The Journal of cell biology · 2014Article
- EB1 accelerates two conformational transitions important for microtubule maturation and dynamics.Current biology : CB · 2014Article
- Bending the rules: widefield microscopy and the Abbe limit of resolution.Journal of cellular physiology · 2014Review
- Data-adaptive image-denoising for detecting and quantifying nanoparticle entry in mucosal tissues through intravital 2-photon microscopy.Beilstein journal of nanotechnology · 2014Article
- Analysis and Modeling of Chromosome Congression During Mitosis in the Chemotherapy Drug Cisplatin.Cellular and molecular bioengineering · 2013Article
- The spatial segregation of pericentric cohesin and condensin in the mitotic spindle.Molecular biology of the cell · 2013Article
- Monitoring actin cortex thickness in live cells.Biophysical journal · 2013Article
- Intellectual immigration.Current biology : CB · 2013Article
- Pericentric chromatin loops function as a nonlinear spring in mitotic force balance.The Journal of cell biology · 2013Article
- A linear optimal transportation framework for quantifying and visualizing variations in sets of images.International journal of computer vision · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Digital fluorescence microscopy is commonly used to track individual proteins and their dynamics in living cells. However, extracting molecule-specific information from fluorescence images is often limited by the noise and blur intrinsic to the cell and the imaging system. Here we discuss a method called "model-convolution," which uses experimentally measured noise and blur to simulate the process of imaging fluorescent proteins whose spatial distribution cannot be resolved. We then compare model-convolution to the more standard approach of experimental deconvolution. In some circumstances, standard experimental deconvolution approaches fail to yield the correct underlying fluorophore distribution. In these situations, model-convolution removes the uncertainty associated with deconvolution and therefore allows direct statistical comparison of experimental and theoretical data. Thus, if there are structural constraints on molecular organization, the model-convolution method better utilizes information gathered via fluorescence microscopy, and naturally integrates experiment and theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.